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PAK2 抗体 (Ser192)

Name: PAK2 抗体 (Ser192)
Brand: antibodies-online
SKU: ABIN7180066
Availability: OutOfStock

PAK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from HepG2 cells, treated with serum (20 % , 15 mins), using PAK2 (Ab-192) antibody.

1 image

产品编号 ABIN7180066

发货至: 中国

Datasheet as PDF

抗原 See all PAK2 抗体

PAK2 (P21-Activated Kinase 2 (PAK2))
抗原表位
12

10

10

8

7

6

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Ser192
适用
95

54

53

3

1

1
人
宿主
93

4
兔
Compatible Secondaries
克隆类型
83

14
多克隆
标记
57

6

5

5

5

5

5

5

1

1

1

1
This PAK2 antibody is un-conjugated
应用范围
57

45

25

16

5

4

3

3

3

3

3

2

1
Western Blotting (WB), ELISA

交叉反应

人, 小鼠

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

免疫原

Synthesized non-phosphopeptide derived from Human PAK2 around the phosphorylation site of serine 192 (T-K-S(p)-I-Y).

亚型

IgG

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anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody
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anti-P21-Activated Kinase 2 (PAK2) (pSer20) antibody
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anti-P21-Activated Kinase 2 (PAK2) (Ser62) antibody
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应用备注

WB:1:500-1:3000,

限制

仅限研究用
状态

Liquid

缓冲液

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

PAK2 (P21-Activated Kinase 2 (PAK2))

别名

PAK2 (PAK2 产品)

别名

PAK65 antibody, PAKgamma antibody, gamma-PAK antibody, 5330420P17Rik antibody, A130002K10Rik antibody, AI836325 antibody, D16Ertd269e antibody, PAK-2 antibody, mKIAA4182 antibody, pak2 antibody, cb422 antibody, kinase antibody, zgc:91798 antibody, wu:fb71h01 antibody, si:dz198m22.1 antibody, pak65 antibody, pakgamma antibody, PAKI antibody, Pak3 antibody, CH73-159L23.1 antibody, wu:fc52b03 antibody, zgc:113857 antibody, p21 (RAC1) activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2a antibody, p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog antibody, p21 protein (Cdc42/Rac)-activated kinase 2b antibody, PAK2 antibody, Pak2 antibody, pak2a antibody, pak2.S antibody, pak2b antibody

背景

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

Martin G.A.,EMBO J. 14:1970-1978(1995).
The MGC Project Team,Genome Res. 14:2121-2127(2004).
Olsen J.V.,Cell 127:635-648(2006).
Aliases: C-t-PAK2 antibody, CB422 antibody, EC 2.7.11.1 antibody, Gamma PAK antibody, Gamma-PAK antibody, hPAK65 antibody, Kinase antibody, p21 (CDKN1A) activated kinase 2 antibody, p21 (CDKN1A)-activated kinase 2a antibody, p21 activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2 antibody, p21 protein Cdc42 Rac activated kinase 2 antibody, p21-activated kinase 2 antibody, p21-activated kinase, 65-KD antibody, p21-activated protein kinase I antibody, p21CDKN1A activated kinase 2 antibody, p27 antibody, p34 antibody, p58 antibody, p65PAK antibody, PAK 2 antibody, PAK-2 antibody, PAK-2p34 antibody, Pak2 antibody, PAK2_HUMAN antibody, PAK65 antibody, PAKgamma antibody, S6 H4 kinase antibody, S6/H4 kinase antibody, Serine threonine protein kinase PAK 2 antibody, Serine/threonine protein kinase PAK 2 antibody

UniProt

Q13177

途径

MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha