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抗Human MAP2K2 抗体:
抗Mouse (Murine) MAP2K2 抗体:
抗Rat (Rattus) MAP2K2 抗体:
Human Polyclonal MAP2K2 Primary Antibody for IF, WB - ABIN1882178
Burroughs, Oh, Barrett, DiAugustine et al.: Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible ... in Molecular cancer research : MCR 2003
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Human Polyclonal MAP2K2 Primary Antibody for IHC (p), WB - ABIN1881526
Tran, Maurer, Nagamine: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. in Molecular and cellular biology 2003
Show all 5 Pubmed References
Data show that SAM and SH3 domain containing 1 (显示 SASH1 抗体) protein (SASH1 (显示 SASH1 抗体)) binds with mitogen-activated protein kinase kinase 2 (MAP2K2), and SASH1 (显示 SASH1 抗体) mutations promote binding between SASH1 (显示 SASH1 抗体) and MAP2K2.
findings demonstrate the interaction of tRNA with MEK2 in pancreatic cancer cells and suggest that tRNA may impact MEK2 activity in cancer cells
Report a synthetic lethal interaction of cetuximab in combination with MEK1 (显示 MAP2K1 抗体)/2 inhibition for the NRAS (显示 NRAS 抗体) mutant subgroup of metastatic colorectal cancer.
There are no other biomarkers correlated with treatment responses following MEK1 (显示 MAP2K1 抗体)/2 inhibition.
MEK2 was essential for the phosphorylation of MKK3 (显示 MAP2K3 抗体)/MKK6 (显示 MAP2K6 抗体) and p38 MAPK (显示 MAPK14 抗体) that directly impacted on cyclin D1 (显示 CCND1 抗体) expression.
High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (显示 ICAM1 抗体)), ezrin (EZR (显示 EZR 抗体)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase (显示 NOS 抗体) 3 (NOS3 (显示 NANOS3 抗体)) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (显示 PTPN11 抗体)) syndrome
Data show that mitogen-activated protein kinase (显示 MAPK1 抗体) kinases MEK1 (显示 MAP2K1 抗体)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (显示 MAPK1 抗体) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
data suggest that, although short-term suppression of Mek1 (显示 MAP2K1 抗体)/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Erk5 (显示 MAPK7 抗体) MAP kinase (显示 MAPK1 抗体) is activated in response to PDGF (显示 PDGFA 抗体)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (显示 MAP3K2 抗体), Mek1 (显示 MAP2K1 抗体)/2, Mek5 (显示 MAP2K5 抗体), PI3-kinase (显示 PIK3CA 抗体) and protein kinase C (PKC (显示 PKC 抗体)).
fluid shear stress induces autocrine TGF-beta (显示 TGFB1 抗体)/ALK5 (显示 TGFBR1 抗体)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (显示 MAP2K1 抗体)/2-mediated signaling.
FGF2 (显示 FGF2 抗体) is an extracellular inducer of COUP-TFII (显示 NR2F2 抗体) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (显示 NR2F2 抗体) expression prior to the onset of osteogenic differentiation
REDD1 (显示 DDIT4 抗体) is required for normal insulin (显示 INS 抗体)-stimulated signaling, and a subtle balance exists between MEK1 (显示 MAP2K1 抗体)/2, REDD1 (显示 DDIT4 抗体), and mTOR (显示 FRAP1 抗体)
MEK1 (显示 MAP2K1 抗体) and MEK2 can substitute for each other but a minimum amount of MEK (显示 MDK 抗体) is critical for placenta development and embryo survival
MK2 (显示 KCNA2 抗体)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (显示 KCNA2 抗体) attenuates dendritic cell-mediated Th1 (显示 HAND1 抗体) differentiation and autoimmune encephalomyelitis.
analysis of p38 (显示 CRK 抗体)-MK2 (显示 KCNA2 抗体)-activated Rsk (显示 RPS6KA1 抗体) signaling in toll (显示 TLR4 抗体)-like receptor-stimulated dendritic cells
both MEK1 (显示 MAP2K1 抗体) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
the AtMKK2-AtMPK10 (显示 MAPK10 抗体) MAPK (显示 MAPK1 抗体) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (显示 MAPK4 抗体) activation concomitantly with MEKK1 (显示 MAP3K1 抗体) and MKK2 phosphorylation.
Ca(2 (显示 CA2 抗体)+) signaling occurred upstream of the MEKK1 (显示 MAP3K1 抗体)-MKK2 pathway. MEKK1 (显示 MAP3K1 抗体) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (显示 MAP3K1 抗体).
Data indicate that MEKK2 (显示 MAP3K2 抗体) is required for the mekk1 (显示 MAP3K1 抗体), mkk1 (显示 MAP2K1 抗体) mkk2, and mpk4 (显示 MAPK4 抗体) autoimmune phenotypes.
Data suggest that the MEKK1 (显示 MAP3K1 抗体)-MKK1 (显示 MAP2K1 抗体)/MKK2-MPK4 (显示 MAPK4 抗体) kinase cascade negatively regulates MEKK2 (显示 MAP3K2 抗体) and activation of MEKK2 (显示 MAP3K2 抗体) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (显示 MAP2K1 抗体)/2) of MKK1 (显示 MAP2K1 抗体) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (显示 MAPK4 抗体) by flg22 is impaired in the mkk1 (显示 MAP2K1 抗体) mkk2 double mutants, suggesting that MKK1 (显示 MAP2K1 抗体) and MKK2 function together with MPK4 (显示 MAPK4 抗体) and MEKK1 (显示 MAP3K1 抗体) in a MAP kinase (显示 MAPK1 抗体) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, MAPKK 2
, MEK 2
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, mitogen-activated protein kinase kinase type 2
, dual specificity mitogen activated protein kinase kinase 2