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抗Rat (Rattus) JNK 抗体:
Cow (Bovine) Polyclonal JNK Primary Antibody for IF (p), IHC (p) - ABIN732368
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
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Human Monoclonal JNK Primary Antibody for IP, WB - ABIN967330
Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996
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Human Monoclonal JNK Primary Antibody for FACS, WB - ABIN968867
Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001
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Human Monoclonal JNK Primary Antibody for FACS, WB - ABIN968866
Kyriakis, Avruch: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. in Physiological reviews 2001
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Human Monoclonal JNK Primary Antibody for ICS - ABIN1177076
Huang, Shi, Chi: Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. in Cytokine 2009
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Human Monoclonal JNK Primary Antibody for ICS - ABIN1177075
Wagner, Nebreda: Signal integration by JNK and p38 MAPK pathways in cancer development. in Nature reviews. Cancer 2009
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Human Polyclonal JNK Primary Antibody for IHC, IHC (p) - ABIN4327961
Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. in Journal of hepatology 2016
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Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody for IHC (p), IHC - ABIN151424
Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Polyclonal JNK Primary Antibody for WB - ABIN3043004
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. in Molecular medicine reports 2014
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Human Polyclonal JNK Primary Antibody for ICC, IF - ABIN4327964
Tian, Guo, Liu, Liu, Weng, Dong, Knowlton, Yuan, Lin: Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. in Cardiovascular research 2013
aken together, these results reveal that inactivation of Rpd3 (显示 HDAC1 抗体) independently regulates JNK and Yki (显示 YAP1 抗体) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (显示 HDAC1 抗体) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (显示 JAK3 抗体)/STAT (显示 STAT1 抗体) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (显示 EGFR 抗体)) pathway in the lateral epidermis for sustained dpp (显示 TGFb 抗体) expression in the LE. Specifically, we demonstrate that Egfr (显示 EGFR 抗体) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (显示 SCRIB 抗体)) tumors requires bZIP protein Fos, the ETS (显示 ETS1 抗体)-domain factor Ets21c and the nuclear receptor Ftz-F1 (显示 NR5A2 抗体), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (显示 ROS1 抗体)/JNK/p38 (显示 MAPK14 抗体)/Upd (显示 UROD 抗体) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (显示 NOTCH1 抗体)-Src (显示 SRC 抗体) synergy.
This study demonstrated that the mechanism by which Bsk (显示 FRK 抗体) is required for pruning is through reducing the membrane levels of the adhesion molecule (显示 NCAM1 抗体) Fasciclin II (显示 NCAM2 抗体) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (显示 AMPH 抗体)-PNP (显示 NP 抗体)) and magnesium.
ERK1 (显示 MAPK3 抗体) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (显示 JUN 抗体) Activity and Cell Transformation.
TGM2 (显示 TGM2 抗体) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (显示 FOSB 抗体)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (显示 LYZ 抗体) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (显示 MAP2K7 抗体), thus disrupting JNK phosphorylation and activation.
The surface immune molecule CD274 (显示 CD274 抗体) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (显示 CD274 抗体)/JNK/Cyclin D2 (显示 CCND2 抗体) pathway promotes the cell cycle entry of LIC.
These data implicate HTRA1 (显示 HTRA1 抗体) as a negative regulator of mesenchymal stem cell adipogenesis.
Our findings indicate that GADD45 (显示 GADD45A 抗体) essentially suppresses the MKK7 (显示 MAP2K7 抗体)-JNK pathway and suggest that differentially expressed GADD45 (显示 GADD45A 抗体) family members fine-tune stress-inducible JNK activity.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
post-translational modification facilitates the mobilization of SIRT6 (显示 SIRT6 抗体) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (显示 PARP1 抗体)) to DNA break sites and for efficient repair of double-strand break.
PRDM5 (显示 PRDM5 抗体) promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 (显示 PRDM5 抗体) may be promising for the therapy of melanoma.
This study showed that the induction level of IL-32 (显示 IL32 抗体) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (显示 IRF6 抗体)-induced IL-32 (显示 IL32 抗体) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (显示 TLR4 抗体)/JNK/AKT (显示 AKT1 抗体)/CREB (显示 CREB1 抗体) signaling pathway.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (显示 PLA2G2A 抗体) keratinocytes showed enhanced activation of EGFR (显示 EGFR 抗体) and JNK1/2 that led to c-Jun (显示 JUN 抗体) activation.
p53 (显示 TP53 抗体) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (显示 PTF1A 抗体)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (显示 PTF1A 抗体)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (显示 CCL20 抗体) secretion
BOC (显示 BOC 抗体) interacts with ABL (显示 ABL1 抗体) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
The authors have found that JNK signaling is required for proper vascular morphogenesis and the normal formation of collateral arteries in muscle.
JNK1-mediated NLRP3 (显示 NLRP3 抗体) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (显示 NLRP3 抗体) inflammasome activation.
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (显示 CASP3 抗体)-dependent Proteolysis of JNK1-2 and Bid (显示 BID 抗体).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (显示 GUSB 抗体).
Data show that the death pathway is independent of ERK (显示 MAPK1 抗体) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (显示 CDK1 抗体) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (显示 CA2 抗体))+ and ROS (显示 ROS1 抗体) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (显示 CA2 抗体))+/CaMs and MAP kinase (显示 MAPK1 抗体) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (显示 ROS1 抗体) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (显示 MAPK14 抗体) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (显示 AXIN1 抗体)/JNK signaling and its inhibitor Aida (显示 AIDA 抗体) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (显示 MMP13 抗体) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (显示 INS 抗体)-IGF-1 (显示 IGF1 抗体) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (显示 MAPK1 抗体) (MAPK (显示 MAPK1 抗体)) signaling pathway, which is regulated by MLK-1 (显示 MAP3K9 抗体) MAPK (显示 MAPK1 抗体) kinase kinase (MAPKKK), MEK-1 (显示 MAP2K1 抗体) MAPK (显示 MAPK1 抗体) kinase (MAPKK), and KGB-1 (显示 KCNJ3 抗体) JNK-like MAPK (显示 MAPK1 抗体).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8