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抗Human JNK 抗体:
抗Mouse (Murine) JNK 抗体:
抗Rat (Rattus) JNK 抗体:
Cow (Bovine) Polyclonal JNK Primary Antibody for IF (p), IHC (p) - ABIN732368
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
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Human Monoclonal JNK Primary Antibody for ICS - ABIN1177076
Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001
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Human Monoclonal JNK Primary Antibody for ICS - ABIN1177075
Huang, Shi, Chi: Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. in Cytokine 2009
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Human Polyclonal JNK Primary Antibody for WB - ABIN3043004
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. in Molecular medicine reports 2014
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Human Polyclonal JNK Primary Antibody for IHC, IHC (p) - ABIN4327961
Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. in Journal of hepatology 2016
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Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody for IHC (p), IHC - ABIN151424
Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Cow (Bovine) Polyclonal JNK Primary Antibody for IF (p) - ABIN732375
Iriyama, Hatta, Takei: Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes. in Cancer medicine 2016
Human Monoclonal JNK Primary Antibody for ELISA, WB - ABIN2475178
Sehgal, Ram: Network Motifs in JNK Signaling. in Genes & cancer 2013
Human Monoclonal JNK Primary Antibody for WB - ABIN2725437
Sung, Liang, Lee, Yen, Hsiao, Wang, Jiang-Shieh, Tsai, Chen: The protective effect of eupafolin against TNF-?-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. in Journal of ethnopharmacology 2015
Human Polyclonal JNK Primary Antibody for IF (p), IHC (p) - ABIN747713
Li, Qiu, Lin, He, Hua, Yuan, Liu, Wei: c-Jun N-terminal kinase is upregulated in patients with hypospadias. in Urology 2012
CXCL12 (显示 CXCL12 抗体) activates the MEKK1 (显示 MAP3K1 抗体)/JNK signaling pathway, which in turn initiates SMAD3 (显示 SMAD3 抗体) phosphorylation, its translocation to nuclei, and recruitment of SMAD3 (显示 SMAD3 抗体) to the CTGF (显示 CTGF 抗体) promoter, which ultimately induces CTGF (显示 CTGF 抗体) expression in human lung fibroblasts.
Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun (显示 JUN 抗体).
Inhibition of each TGFbeta (显示 TGFB1 抗体) receptor-I, glucocorticoid receptor (显示 NR3C1 抗体) or JNK signaling partially reversed the dexamethasone-mediated effects, suggesting a complex signaling network. These data reveal that dexamethasone mediates progression by membrane effects and binding to glucocorticoid receptor (显示 NR3C1 抗体)
JNK inhibitor prevents SIRT1 (显示 SIRT1 抗体) phosphorylation, leading to elevated SIRT1 (显示 SIRT1 抗体) protein levels even in the presence of H2O2. Taken together, our results indicate that CHFR (显示 CHFR 抗体) plays a crucial role in the cellular stress response pathway by controlling the stability and function of SIRT1 (显示 SIRT1 抗体).
Findings suggest that during lipoapoptosis, HCV infection may enhance hepatocyte toxicity by increasing JNK phosphorylation.
High JNK expression is associated with non-small-cell lung cancer.
These data suggested that Annexin A2 (显示 ANXA2 抗体) induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 (显示 TP53 抗体) signaling, and provided an evidence that blockade of Annexin A2 (显示 ANXA2 抗体) could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs
Data suggest that H2O2 regulates cell death in granulosa cells via the ROS (显示 ROS1 抗体)-JNK-p53 (显示 TP53 抗体) pathway.
High expression of JNK is associated with invasion of gastric cancer.
JNK activation and signaling in extrahepatic cholangiocarcinoma is regulated by L1CAM.JNK role in cell migration in extrahepatic cholangiocarcinoma.
Findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning.
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (显示 INS 抗体)-IGF-1 (显示 IGF1 抗体) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (显示 MAPK1 抗体) (MAPK (显示 MAPK1 抗体)) signaling pathway, which is regulated by MLK-1 (显示 MAP3K9 抗体) MAPK (显示 MAPK1 抗体) kinase kinase (MAPKKK), MEK-1 (显示 MAP2K1 抗体) MAPK (显示 MAPK1 抗体) kinase (MAPKK), and KGB-1 (显示 KCNJ3 抗体) JNK-like MAPK (显示 MAPK1 抗体).
Noise exposure led to enhanced JNK phosphorylation and IRS1 (显示 IRS1 抗体) serine phosphorylation as well as reduced Akt (显示 AKT1 抗体) phosphorylation in skeletal muscles in response to exogenous insulin (显示 INS 抗体) stimulation.
Prdx1 (显示 PRDX1 抗体) knockout can aggravate the oxidative stress and lung injury by increasing the level of Reactive Oxygen Species (ROS (显示 ROS1 抗体)), and also activate P38 (显示 CRK 抗体)/JNK signaling pathway.
Data identify a unique signal crosstalk between Wnt (显示 WNT2 抗体) signaling and the MAP3K1 (显示 MAP3K1 抗体)-JNK pathway in epithelial morphogenesis.
Therefore, APP (显示 APP 抗体) modulates Nav1.6 (显示 SCN8A 抗体) sodium channels through a Go-coupled JNK pathway, which is dependent on phosphorylation of APP (显示 APP 抗体) at Thr668.
These interactions are required for SRC (显示 SRC 抗体)-induced activation of VAV (显示 VAV1 抗体) and the subsequent engagement of a JIP1 (显示 MAPK8IP1 抗体)-tethered JNK signaling module.
this study establishes that JNK1 is a key mediator of osteoblast function in vivo and in vitro.
Jnk1 deficiency inhibits the development of neural stem cells/precursors
Suppressing P38 (显示 CRK 抗体) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK (显示 JAK3 抗体)/STAT (显示 STAT1 抗体) activation was suppressed by fusion-inducing JNK signaling.
aken together, these results reveal that inactivation of Rpd3 (显示 HDAC1 抗体) independently regulates JNK and Yki (显示 YAP1 抗体) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (显示 HDAC1 抗体) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (显示 JAK3 抗体)/STAT (显示 STAT1 抗体) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (显示 EGFR 抗体)) pathway in the lateral epidermis for sustained dpp (显示 TGFb 抗体) expression in the LE. Specifically, we demonstrate that Egfr (显示 EGFR 抗体) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (显示 SCRIB 抗体)) tumors requires bZIP protein Fos, the ETS (显示 ETS1 抗体)-domain factor Ets21c and the nuclear receptor Ftz-F1 (显示 NR5A2 抗体), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (显示 ROS1 抗体)/JNK/p38 (显示 MAPK14 抗体)/Upd (显示 UROD 抗体) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (显示 NOTCH1 抗体)-Src (显示 SRC 抗体) synergy.
This study demonstrated that the mechanism by which Bsk (显示 FRK 抗体) is required for pruning is through reducing the membrane levels of the adhesion molecule (显示 NCAM1 抗体) Fasciclin II (显示 NCAM2 抗体) (FasII)
Porcine reproductive and respiratory syndrome virus -activated TAK-1 (显示 NR2C2 抗体) was essential for the activation of JNK and NF-kappaB (显示 NFKB1 抗体) pathways and IL-8 (显示 IL8 抗体) expression.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1/2 dependent.
These data suggest that the p38 (显示 MAPK14 抗体) and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
based on the data, we can conclude that JNK plays an active role in fragmentation of pig oocytes and that p38 MAPK (显示 MAPK14 抗体) is not involved in this process
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
PP2A (显示 PPP2R2B 抗体) and AIP1 (显示 PDCD6IP 抗体) cooperatively induce activation of ASK1 (显示 MAP3K5 抗体)-JNK signaling and vascular endothelial cell apoptosis.
Phorbol 12-myristate 13-acetate activation of ERK (显示 MAPK1 抗体) and JNK signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
study reports MPK8 connects protein phosphorylation, Ca(2 (显示 CA2 抗体))+ and ROS (显示 ROS1 抗体) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (显示 CA2 抗体))+/CaMs and MAP kinase (显示 MAPK1 抗体) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (显示 ROS1 抗体) homeostasis
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (显示 CASP3 抗体)-dependent Proteolysis of JNK1-2 and Bid (显示 BID 抗体).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (显示 GUSB 抗体).
Data show that the death pathway is independent of ERK (显示 MAPK1 抗体) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (显示 CDK1 抗体) and JNK.
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (显示 MAPK14 抗体) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (显示 AXIN1 抗体)/JNK signaling and its inhibitor Aida (显示 AIDA 抗体) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (显示 MMP13 抗体) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Suggest that hypoxia-induced modified cells engage the PDGFbeta-R-JNK1 axis to confer distinctively heightened proliferation and adventitial remodelling in pulmonary hypertension.
These data suggest a differential requirement of JNK1 and p38 MAPK (显示 MAPK14 抗体) in TNF (显示 TNF 抗体) regulation of E2F1 (显示 E2F1 抗体). Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (显示 TNF 抗体)-mediated EC dysfunction.
PKD (显示 PRKD1 抗体) is a critical mediator in H2O2- but not TNF (显示 TNF 抗体)-induced ASK1 (显示 MAP3K5 抗体)-JNK signaling
ATF3 (显示 ATF3 抗体) induction by acute hypoxia is mediated by nitric oxide and the JNK pathway in endothelial cells
JNK plays an important role in the induction of apoptosis in transformed bovine brain endothelial cells stimulated by LPS (显示 IRF6 抗体)
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, janus kinase 1
, mitogen-activated protein kinase 8