This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
Flach, Leu, Martinisi, Skachokova, Frank, Tolnay, Stahlberg, Winkler: "Trans-seeding of Alzheimer-related tau protein by a yeast prion." in: Alzheimer's & dementia : the journal of the Alzheimer's Association, Vol. 18, Issue 12, pp. 2481-2492, (2023) (PubMed).
Aliases for MAPT 蛋白
microtubule associated protein tau (MAPT) 蛋白 microtubule-associated protein tau (Mapt) 蛋白 microtubule associated protein tau S homeolog (mapt.S) 蛋白 microtubule-associated protein tau (LOC5580230) 蛋白 microtubule-associated protein tau (CpipJ_CPIJ013260) 蛋白 Microtubule-associated protein tau (tau) 蛋白 microtubule associated protein tau (Mapt) 蛋白 solute carrier family 6 (neurotransmitter transporter), member 6b (slc6a6b) 蛋白 AI413597 蛋白 AW045860 蛋白 DDPAC 蛋白 FTDP-17 蛋白 MAPT 蛋白 MAPTL 蛋白 MSTD 蛋白 Mtapt 蛋白 MTBT1 蛋白 MTBT2 蛋白 PHF-tau 蛋白 PPND 蛋白 pTau 蛋白 RNPTAU 蛋白 slc6a6 蛋白 TAU 蛋白 Tau 蛋白 tau 蛋白 taut 蛋白 wu:fc26e12 蛋白 xtp 蛋白