MAP4K4 蛋白
(Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Aliases for MAP4K4 蛋白
mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) 蛋白mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) 蛋白
9430080K19Rik 蛋白
AU043147 蛋白
AU045934 蛋白
AW046177 蛋白
FLH21957 蛋白
HGK 蛋白
MEKKK4 蛋白
NIK 蛋白
Nik 蛋白
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