MAP3K9 抗体
(Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
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Latest Publications for our MAP3K9 抗体
: "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." in: Hearing research, Vol. 270, Issue 1-2, pp. 21-7, (2011) (PubMed).: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).
: "Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation." in: BMC genomics, Vol. 10, pp. 67, (2009) (PubMed).
: "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop." in: Biochemistry, Vol. 43, Issue 51, pp. 16348-55, (2004) (PubMed).
: "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47922-7, (2003) (PubMed).
: "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis." in: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4713-24, (2001) (PubMed).
Aliases for MAP3K9 抗体
mitogen-activated protein kinase kinase kinase 9 (MAP3K9) 抗体mitogen-activated protein kinase kinase kinase 9 (Map3k9) 抗体
E130314H24Rik 抗体
MEKK9 抗体
MLK1 抗体
Mlk1 抗体
PRKE1 抗体
Prke1 抗体
RGD1562149 抗体
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