MAP3K8 抗体
(Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| MAP3K8 抗体 (pThr290) (Alexa Fluor 555) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (pSer400) (Alexa Fluor 555) | 人 | 兔 Polyclonal |
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| MAP3K8 抗体 (pThr290) (Biotin) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (pSer400) (Biotin) | 人 | 兔 Polyclonal |
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| MAP3K8 抗体 (pThr290) (Alexa Fluor 680) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (pSer400) (Alexa Fluor 680) | 人 | 兔 Polyclonal |
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| MAP3K8 抗体 (pSer400) (Alexa Fluor 647) | 人 | 兔 Polyclonal |
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| MAP3K8 抗体 (pThr290) (Alexa Fluor 647) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (pThr290) (Alexa Fluor 750) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (pSer400) (Alexa Fluor 750) | 人 | 兔 Polyclonal |
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| MAP3K8 抗体 (pThr290) (Alexa Fluor 594) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (pSer400) (Alexa Fluor 594) | 人 | 兔 Polyclonal |
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| MAP3K8 抗体 (pSer400) (Alexa Fluor 488) | 人 | 兔 Polyclonal |
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| MAP3K8 抗体 (pThr290) (Alexa Fluor 488) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (AA 360-470) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (AA 360-470) (FITC) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (Biotin) | 人, 大鼠, 小鼠 | 兔 Polyclonal |
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| MAP3K8 抗体 (N-Term) | 人 | 兔 Polyclonal |
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Primary Antibody
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 555
- 抗原表位
- pThr290
Primary Antibody
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 555
- 抗原表位
- pSer400
Primary Antibody
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Biotin
- 抗原表位
- pThr290
Primary Antibody
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 680
- 抗原表位
- pThr290
Primary Antibody
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 680
- 抗原表位
- pSer400
Primary Antibody
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 647
- 抗原表位
- pSer400
Primary Antibody
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 647
- 抗原表位
- pThr290
Primary Antibody
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 750
- 抗原表位
- pThr290
Primary Antibody
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 750
- 抗原表位
- pSer400
Primary Antibody
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 594
- 抗原表位
- pThr290
Primary Antibody
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 594
- 抗原表位
- pSer400
Primary Antibody
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 488
- 抗原表位
- pSer400
Primary Antibody
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Alexa Fluor 488
- 抗原表位
- pThr290
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- ELISA (ELISA: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 360-470
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗原表位
- AA 360-470
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Biotin
Primary Antibody
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- N-Term
Latest Publications for our MAP3K8 抗体
: "TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth." in: PLoS ONE, Vol. 6, Issue 1, pp. e16205, (2011) (PubMed).
: "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis." in: Diabetes, Vol. 59, Issue 1, pp. 61-70, (2009) (PubMed).
: "Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7984-93, (2009) (PubMed).
: "When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction." in: Immunity, Vol. 29, Issue 1, pp. 12-20, (2008) (PubMed).
: "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31379-86, (2000) (PubMed).
: "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis." in: Diabetes, Vol. 59, Issue 1, pp. 61-70, (2009) (PubMed).
: "Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7984-93, (2009) (PubMed).
: "When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction." in: Immunity, Vol. 29, Issue 1, pp. 12-20, (2008) (PubMed).
: "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31379-86, (2000) (PubMed).
Aliases for MAP3K8 抗体
mitogen-activated protein kinase kinase kinase 8 (MAP3K8) 抗体mitogen-activated protein kinase kinase kinase 8 (map3k8) 抗体
mitogen-activated protein kinase kinase kinase 8 (Map3k8) 抗体
c-COT 抗体
COT 抗体
Cot 抗体
Cot/Tpl2 抗体
D17TPL2 抗体
EST 抗体
Est 抗体
ESTF 抗体
Estf 抗体
MAP3K8 抗体
MEKK8 抗体
Tpl-2 抗体
TPL2 抗体
Tpl2 抗体
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