MAP2K5 抗体
(Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011].
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Latest Publications for our MAP2K5 抗体
: "Melittin inhibits proliferation, migration and invasion of bladder cancer cells by regulating key genes based on bioinformatics and experimental assays." in: Journal of cellular and molecular medicine, Vol. 24, Issue 1, pp. 655-670, (2021) (PubMed).: "MicroRNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling." in: Scientific reports, Vol. 4, pp. 3819, (2014) (PubMed).
: "Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells." in: International journal of biological sciences, Vol. 10, Issue 2, pp. 171-80, (2014) (PubMed).
: "Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction." in: Circulation research, Vol. 102, Issue 11, pp. 1416-25, (2008) (PubMed).
: "Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation." in: The Journal of biological chemistry, Vol. 279, Issue 2, pp. 1506-12, (2004) (PubMed).
: "MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation." in: Journal of cell science, Vol. 117, Issue Pt 9, pp. 1773-84, (2004) (PubMed).
: "MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion." in: Oncogene, Vol. 22, Issue 9, pp. 1381-9, (2003) (PubMed).
: "MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival." in: Blood, Vol. 102, Issue 3, pp. 1019-27, (2003) (PubMed).
Aliases for MAP2K5 抗体
mitogen activated protein kinase kinase 5 (Map2k5) 抗体mitogen-activated protein kinase kinase 5 (MAP2K5) 抗体
mitogen-activated protein kinase kinase 5 (Map2k5) 抗体
mitogen-activated protein kinase kinase 5 (map2k5) 抗体
mitogen-activated protein kinase kinase 5 L homeolog (map2k5.L) 抗体
MAP kinase kinase 5 (MKK5) 抗体
AI324775 抗体
AI428457 抗体
ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 抗体
ATMAP2K_ALPHA 抗体
ATMEK5 抗体
ATMKK5 抗体
fb73f02 抗体
HsT17454 抗体
MAP2K_A 抗体
MAP KINASE KINASE 5 抗体
MAP kinase kinase 5 抗体
MAPKK5 抗体
Mapkk5 抗体
Mek5 抗体
MEK5 抗体
PRKMK5 抗体
Prkmk5 抗体
wu:fb73f02 抗体
zgc:172137 抗体
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