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LMO2 产品

(LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Categories

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008].

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Featured LMO2 Categories

LMO2 抗体

High quality antibodies with extensive validation data.

LMO2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

LMO2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LMO2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, FACS, StM
Validations
  • (5)
Cat. No. ABIN6939966
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (2)
  • (4)
Cat. No. ABIN1098128
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application FACS, IF
Validations
  • (3)
Cat. No. ABIN6939968
Quantity 100 μg
Datasheet Datasheet

Recommended LMO2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1155675
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1155676
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1155674
Quantity 96 tests
Datasheet Datasheet

Recommended LMO2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309514
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3087066
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133442
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our LMO2 Products

Cheng, Ang, A El Farran, Li, Fang, Liu, Kong, Chin, Ling, Lim, Li, Huber, Loh, Loh, Lim: "Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors." in: Nature communications, Vol. 7, pp. 13396, (2018) (PubMed).

Stanulovic, Cauchy, Assi, Hoogenkamp: "LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage." in: Nucleic acids research, Vol. 45, Issue 17, pp. 9874-9888, (2017) (PubMed).

Sewell, Tanaka, El Omari, Mancini, Cruz, Fernandez-Fuentes, Chambers, Rabbitts: "Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex." in: Scientific reports, Vol. 4, pp. 3643, (2014) (PubMed).

Treanor, Zhou, Janke, Churchman, Ma, Lu, Chen, Mullighan, Sorrentino: "Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential." in: The Journal of experimental medicine, Vol. 211, Issue 4, pp. 701-13, (2014) (PubMed).

Cubedo, Maurin, Jiang, Lossos, Wright: "PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL." in: The FEBS journal, Vol. 278, Issue 17, pp. 3065-75, (2011) (PubMed).

Baecklund, Backlin, Mansouri, Klareskog, Askling, Iliadou, Enblad, Lossos, Natkunam, Rosenquist: "LMO2 protein expression predicts survival in patients with rheumatoid arthritis and diffuse large B-cell lymphoma." in: Leukemia & lymphoma, Vol. 52, Issue 6, pp. 1146-9, (2011) (PubMed).

Hirose, Inukai, Kikuchi, Furukawa, Ikawa, Kawamoto, Oram, G��ttgens, Kiyokawa, Miyagawa, Okita, Akahane, Zhang, Kuroda, Honna, Kagami, Goi, Kurosawa, Look, Matsui, Inaba, Sugita: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, (2010) (PubMed).

Ryu, Evans-Galea, Gray, Bodine, Persons, Nienhuis: "An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation." in: Blood, Vol. 111, Issue 4, pp. 1866-75, (2008) (PubMed).

Natkunam, Zhao, Mason, Chen, Taidi, Jones, Hammer, Hamilton Dutoit, Lossos, Levy: "The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas." in: Blood, Vol. 109, Issue 4, pp. 1636-42, (2007) (PubMed).

Nakayama, Nakayama, Davidson, Sheu, Jinawath, Santillan, Salani, Bristow, Morin, Kurman, Wang, Shih: "A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 49, pp. 18739-44, (2006) (PubMed).

Synonyms and alternative names related to LMO2

LIM domain only 2 (lmo2), LIM domain only 2 (LMO2), LIM domain only 2 (Lmo2), LIM domain only 2 (rhombotin-like 1) (lmo2), LIM domain only 2 S homeolog (lmo2.S), LMO-2, lmo2-A, Rbtn-2, Rbtn2, RBTN2, RBTNL1, Rhom-2, RHOM2, rhombotin-2, Ttg2, TTG2, wu:fc83a08, xlmo2, zgc:111930

Protein level used designations for LMO2

  • Rhombotin-2
  • LIM domain only 2 (rhombotin-like 1)
  • LIM domain only protein 2
  • LIM only 2
  • LMO-2
  • T-cell translocation protein 2
  • cysteine-rich protein TTG-2
  • rhombotin-2
  • T-cell translocation gene 2
  • rhombotin 2
  • rhombotin-like 1
  • LIM domain only-2
  • ttg2
  • zlmo2
  • xLMO-2
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