LATS1 抗体
(LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
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50 results
LATS1
适用: 人, 小鼠, 大鼠
WB, ELISA, IHC, IHC (fro), ICC, FACS
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our LATS1 抗体
: "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle." in: Cells, Vol. 8, Issue 12, (2020) (PubMed).: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 2, pp. G196-204, (2014) (PubMed).
: "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14." in: Oncogene, Vol. 32, Issue 17, pp. 2220-9, (2013) (PubMed).
: "Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity." in: Cancer research, Vol. 71, Issue 5, pp. 2010-20, (2011) (PubMed).
: "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development." in: Development (Cambridge, England), Vol. 138, Issue 5, pp. 947-57, (2011) (PubMed).
: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).
: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).
: "A crucial role of WW45 in developing epithelial tissues in the mouse." in: The EMBO journal, Vol. 27, Issue 8, pp. 1231-42, (2008) (PubMed).
Aliases for LATS1 抗体
large tumor suppressor kinase 1 (LATS1) 抗体large tumor suppressor (Lats1) 抗体
large tumor suppressor kinase 1 (lats1) 抗体
large tumor suppressor kinase 1 (Lats1) 抗体
large tumor suppressor kinase 1 S homeolog (lats1.S) 抗体
AW208599 抗体
Lats 抗体
lats1 抗体
RGD1564085 抗体
si:dkey-181i3.5 抗体
WARTS 抗体
warts 抗体
wts 抗体
wu:fc19a11 抗体
zgc:123219 抗体
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