(Kringle Containing Transmembrane Protein 1 (KREMEN1))
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008].
Ross, Baker, Fisher, Hoff, Pak, Murashov: "miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1." in: Frontiers in cellular neuroscience, Vol. 12, pp. 87, (2018) (PubMed).
Diarra, Stolina, Polzer, Zwerina, Ominsky, Dwyer, Korb, Smolen, Hoffmann, Scheinecker, van der Heide, Landewe, Lacey, Richards, Schett: "Dickkopf-1 is a master regulator of joint remodeling." in: Nature medicine, Vol. 13, Issue 2, pp. 156-63, (2007) (PubMed).