DKK4 ELISA 试剂盒
Quick Overview for DKK4 ELISA 试剂盒 (ABIN5510735)
抗原
See all DKK4 ELISA试剂盒抗原表位
适用
检测方法
实验类型
应用范围
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原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse DKK4
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品牌
- PicoKine™
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Analytical Method
- Quantitative
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特异性
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Expression system for standard: NSO
Immunogen sequence: L19-I221 -
交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
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Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA Kit
DKK4 适用: 人 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA KitDKK4 适用: 小鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum
Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA KitDKK4 适用: 人 Colorimetric Sandwich ELISA 10-10000 pg/mL Cell Culture Supernatant, Plasma, Serum
Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA KitDKK4 适用: 小鼠 Colorimetric Sandwich ELISA 78-5000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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有效期
- 12 months
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- DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
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别名
- Dkk4
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背景
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Protein Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). .
Background: DKK4 is a membersof the Dickkopf family which are negative regulators of the growth-promoting Wnt / beta-catenin signaling pathway. By FISH, the DKK4 gene was mapped to chromosome 8p11.2-p11.1. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. The expression of DKK4 was significantly reduced in hepatocellular carcinomas (HCCs), particularly in HCCs that showed cytoplasmic beta- catenin accumulation. DKK4 expression was also reduced in HCC cell lines. Ectopic expression of DKK4 in 2 HCC cell lines reduced beta-catenin and cyclin D1 protein levels and attenuated beta-catenin activity in reporter gene assays.
Synonyms: Dickkopf-related protein 4,Dickkopf-4,Dkk-4,Dkk4,
Full Gene Name: Dickkopf-related protein 4
Cellular Localisation: Secreted. -
UniProt
- Q8VEJ3
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途径
- WNT signaling
抗原 See all DKK4 ELISA试剂盒
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