ErbB2/Her2 ELISA 试剂盒
Quick Overview for ErbB2/Her2 ELISA 试剂盒 (ABIN5068126)
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See all ErbB2/Her2 ELISA试剂盒抗原表位
适用
检测方法
应用范围
样品类型
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交叉反应 （详细）
- Calculated cross reactivity: Hu
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产品特性
- ErbB2, phosphorylated (Tyr1221/1222), Human (c-erbB2, HER2), ELISA Kit
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Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA Kit
ErbB2/Her2 适用: 人 Colorimetric Sandwich ELISA 0.62 ng/mL - 40 ng/mL Plasma, Serum, Tissue Homogenate
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 人 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Cell Lysate, Plasma, Serum, Tissue Homogenate
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 小鼠 Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Plasma, Serum, Tissue Homogenate
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 大鼠 Colorimetric Sandwich ELISA 0.313 ng/mL - 20 ng/mL Plasma, Serum, Tissue Homogenate
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 大鼠 Colorimetric Sandwich ELISA 0.62 ng/mL - 40 ng/mL Plasma, Serum
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 人 AA 23-652 Colorimetric Sandwich ELISA 62.5-4000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum, Tissue Homogenate
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 人 Colorimetric Sandwich ELISA 8-2000 pg/mL Cell Culture Supernatant, Plasma, Serum
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 人 Soluble Colorimetric Sandwich ELISA 0.312-20 ng/mL Cell Culture Supernatant, Plasma, Serum
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) ELISA KitErbB2/Her2 适用: 人 Colorimetric Sandwich ELISA 62.5 pg/mL - 4000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
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限制
- 仅限研究用
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储存条件
- -20 °C
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储存方法
- -20°C
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- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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别名
- ErbB2
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背景
- The ErbB2 (HER2) proto-oncogene encodes a transmembrane receptor-like glycoprotein of 185kD with intrinsic tyrosine kinase activity (1). ErbB2 does not have any known ligand. However, the kinase activity of ErbB2 can be activated without ligand if it is overexpressed and by heteromeric association with other members of the ErbB family (2). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40 % of human breast cancers (3). Binding of the c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas. Direction of ErbB2 to the c-Cbl-regulated proteolytic pathway may have therapeutic potential. Tyr877 of ErbB2 is homologous to Tyr416 of pp60c-Src, located in the kinase domain. Phosphorylation of this site may be involved in regulation of ErbB2 biological activity. Tyr1248 and Tyr1221/1222 are the major autophosphorylation sites in ErbB2. Phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway (1,5).
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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