IL-24 ELISA 试剂盒
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北京 101111
Quick Overview for IL-24 ELISA 试剂盒 (ABIN4986950)
抗原
See all IL-24 (IL24) ELISA试剂盒适用
检测方法
实验类型
检测范围
应用范围
样品类型
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最低检测浓度
- 62.5 pg/mL
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Analytical Method
- Quantitative
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特异性
- Natural and recombinant Human IL-24/MDA-7 Ligand
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灵敏度
- 30 pg/mL
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试剂未包括
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- Microplate reader.
- Pipettes and pipette tips.
- EP tube Deionized or distilled water.
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Interleukin 24 (IL24) ELISA Kit
IL24 适用: 小鼠 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Interleukin 24 (IL24) ELISA KitIL24 适用: 大鼠 Colorimetric Sandwich ELISA 15.625 pg/mL - 1000 pg/mL Plasma, Serum, Tissue Homogenate
Interleukin 24 (IL24) ELISA KitIL24 适用: 人 Colorimetric Sandwich ELISA 7.8 pg/mL - 500 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Interleukin 24 (IL24) ELISA KitIL24 适用: 大鼠 Colorimetric Sandwich ELISA 15.62 pg/mL - 1000 pg/mL Plasma, Serum
Interleukin 24 (IL24) ELISA KitIL24 适用: 小鼠 AA 27-181 Colorimetric Sandwich ELISA 62.5 pg/mL - 4000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
Interleukin 24 (IL24) ELISA KitIL24 适用: 人 Colorimetric Sandwich ELISA 63-4000 pg/mL Cell Lysate, Plasma, Serum
Interleukin 24 (IL24) ELISA KitIL24 适用: 大鼠 Colorimetric Sandwich ELISA 15.625 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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应用备注
- Detection Wavelength: 450 nm
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样本量
- 20 μL
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实验时间
- 3 h
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C
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- IL-24 (IL24) (Interleukin 24 (IL24))
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别名
- IL-24/MDA-7
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背景
- Interleukin 24(IL-24),also known as mda7 (melanoma differentiation associated gene7),is a member of the IL10 family of helical cytokines. The IL-24 gene encodes a precursor protein of 207 amino acids (aa) that contains a 48 aa signal sequence and an 18 kDa, 158 aa mature segment. There are three potential Nlinked glycosylation sites, at least one of which is used. When secreted, IL-24 is a 3540 kDa phosphorylated glycoprotein that apparently can exist as either a monomer or dimer. It is suggested that glycosylation is essential for activity. Mature human IL-24 shares 69 % aa sequence identity with mouse and rat IL-24. Human IL-24 is also active in rodent systems. Cells known to express IL-24 include B cells, CD4+ T cells, NK cells, lymph node dendritic cells, monocytes, melanocytes, and melanoma cells. Functionally, IL-24 has diverse activities. At low concentrations on monocytes, it induces type I proinflammatory cytokines such as IFN-γ, IL-1β,IL-12, and TNF-α. At high concentrations, it is a strong inducer of apoptosis in tumor cells, but not normal cells. IL-24 also has antiangiogenic properties. It directly binds IL-24 receptors on endothelial cells, activating STAT3 and blocking their differentiation. IL-24 binds and signals through two heterodimeric receptor complexes. One complex is the combination of IL-20Rα and IL-20Rβ, which is shared with IL-19 and IL-20. The second complex is a combination of IL-22R and IL-20Rβ, which is shared with IL-20.
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途径
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagy
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