Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Katoh, Katoh: "Identification and characterization of TRIP8 gene in silico." in: International journal of molecular medicine, Vol. 12, Issue 5, pp. 817-21, (2003) (PubMed).
Lai, Godley, Joslin, Fernald, Liu, Espinosa, Zhao, Pamintuan, Till, Larson, Qian, Le Beau: "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)." in: Genomics, Vol. 71, Issue 2, pp. 235-45, (2001) (PubMed).
Hu, Gomes, Horrigan, Kravarusic, Mar, Arbieva, Chyna, Fulton, Edassery, Raza, Westbrook: "A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31." in: Oncogene, Vol. 20, Issue 47, pp. 6946-54, (2001) (PubMed).