JMY 抗体
(Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
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Latest Publications for our JMY 抗体
: "A transcription co-factor integrates cell adhesion and motility with the p53 response." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 47, pp. 19872-7, (2009) (PubMed).: "p53-cofactor JMY is a multifunctional actin nucleation factor." in: Nature cell biology, Vol. 11, Issue 4, pp. 451-9, (2009) (PubMed).
: "Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients." in: Genes, chromosomes & cancer, Vol. 47, Issue 8, pp. 680-96, (2008) (PubMed).
: "Mdm2 targets the p53 transcription cofactor JMY for degradation." in: EMBO reports, Vol. 8, Issue 1, pp. 84-90, (2007) (PubMed).
: "A novel cofactor for p300 that regulates the p53 response." in: Molecular cell, Vol. 4, Issue 3, pp. 365-76, (1999) (PubMed).
Aliases for JMY 抗体
junction mediating and regulatory protein, p53 cofactor (JMY) 抗体junction mediating and regulatory protein, p53 cofactor (jmy) 抗体
junction-mediating and regulatory protein (Jmy) 抗体
WHDC1L3 抗体
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