IRF9 抗体
(Interferon Regulatory Factor 9 (IRF9))
Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
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Latest Publications for our IRF9 抗体
: "JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response." in: mBio, Vol. 7, Issue 4, (2016) (PubMed).: "Toll-like receptor 3 stimulation promotes Ro52/TRIM21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway." in: Clinical and experimental immunology, Vol. 178, Issue 3, pp. 548-60, (2014) (PubMed).
: "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape." in: Nature medicine, Vol. 18, Issue 8, pp. 1224-31, (2013) (PubMed).
: "Structural basis of core promoter recognition in a primitive eukaryote." in: Cell, Vol. 115, Issue 4, pp. 413-24, (2003) (PubMed).
: "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 274, Issue 34, pp. 24059-65, (1999) (PubMed).
: "Dynamic redistribution of STAT1 protein in IFN signaling visualized by GFP fusion proteins." in: European journal of biochemistry / FEBS, Vol. 260, Issue 1, pp. 137-44, (1999) (PubMed).
: "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins." in: Molecular and cellular biology, Vol. 12, Issue 8, pp. 3315-24, (1992) (PubMed).
Aliases for IRF9 抗体
interferon regulatory factor 9 (IRF9) 抗体interferon regulatory factor 9 (irf9) 抗体
interferon regulatory factor 9 (Irf9) 抗体
IRF-9 抗体
Irf-9 抗体
ISGF3 抗体
ISGF3G 抗体
Isgf3g 抗体
p48 抗体
zgc:92097 抗体
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