This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Balaci, Spada, Olla, Sole, Loddo, Anedda, Naitza, Zuncheddu, Maschio, Altea, Uda, Pilia, Sanna, Masala, Crisponi, Fattori, Devoto, Doratiotto, Rassu, Mereu, Giua, Cadeddu, Atzeni, Pelosi, Corrias et al.: "IRAK-M is involved in the pathogenesis of early-onset persistent asthma. ..." in: American journal of human genetics, Vol. 80, Issue 6, pp. 1103-14, (2007) (PubMed).
Rosati, Martin: "Identification and characterization of murine IRAK-M." in: Biochemical and biophysical research communications, Vol. 293, Issue 5, pp. 1472-7, (2002) (PubMed).