IMPA1 抗体
(Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009].
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33 results :
IMPA1
适用: 人, 小鼠, 大鼠, 豚鼠, 兔, Cow, 犬, 马, Pig
WB
宿主: 兔
Polyclonal
unconjugated
1 image
Latest Publications for our IMPA1 抗体
: "An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons." in: Nature neuroscience, Vol. 13, Issue 3, pp. 291-301, (2010) (PubMed).: "A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after ?-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination." in: Neurochemistry international, Vol. 56, Issue 8, pp. 871-7, (2010) (PubMed).
Aliases for IMPA1 抗体
inositol monophosphatase 1 (impa1) 抗体inositol(myo)-1(or 4)-monophosphatase 1 (impa1) 抗体
inositol (myo)-1(or 4)-monophosphatase 1 (Impa1) 抗体
inositol monophosphatase 1 (Impa1) 抗体
inositol monophosphatase (impa1) 抗体
inositol monophosphatase 1 (IMPA1) 抗体
inositol(myo)-1(or 4)-monophosphatase 1 S homeolog (impa1.S) 抗体
inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1) 抗体
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2900059K10Rik 抗体
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impa 抗体
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