IL12RB1 抗体
(Interleukin 12 Receptor beta 1 (IL12RB1))
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Latest Publications for our IL12RB1 抗体
: "Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege." in: PLoS ONE, Vol. 9, Issue 4, pp. e96120, (2014) (PubMed).: "Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency." in: The Journal of allergy and clinical immunology, Vol. 131, Issue 4, pp. 1146-56, 1156.e1-5, (2013) (PubMed).
: "IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia." in: Blood, Vol. 120, Issue 18, pp. 3774-82, (2012) (PubMed).
: "Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo." in: Leukemia, Vol. 26, Issue 6, pp. 1365-74, (2012) (PubMed).
: "Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans." in: Journal of dermatological science, Vol. 57, Issue 3, pp. 199-206, (2010) (PubMed).
: "Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription." in: Cellular immunology, Vol. 241, Issue 1, pp. 7-13, (2006) (PubMed).
: "A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors." in: Blood, Vol. 104, Issue 7, pp. 2095-101, (2004) (PubMed).
: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, (2000) (PubMed).
: "Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits." in: European journal of immunology, Vol. 29, Issue 6, pp. 2007-13, (1999) (PubMed).
: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).
Aliases for IL12RB1 抗体
interleukin 12 receptor subunit beta 1 (Il12rb1) 抗体interleukin 12 receptor subunit beta 1 (IL12RB1) 抗体
interleukin 12 receptor, beta 1 (Il12rb1) 抗体
CD212 抗体
IL-12R 抗体
IL-12R-BETA1 抗体
IL-12R[b] 抗体
Il12rb 抗体
IL12RB 抗体
IL12RB1 抗体
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