IL-5 蛋白
(Interleukin 5 (IL5))
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008].
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Latest Publications for our IL-5 蛋白
: "Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells." in: Journal of virology, Vol. 80, Issue 24, pp. 11899-910, (2006) (PubMed).: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1." in: International immunology, Vol. 3, Issue 6, pp. 571-7, (1991) (PubMed).
: "Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin." in: Journal of cellular physiology, Vol. 140, Issue 2, pp. 323-34, (1989) (PubMed).
: "Structure and function of interleukin 4 and 5." in: Immunological reviews, Vol. 102, pp. 189-212, (1988) (PubMed).
: "Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II." in: Nature, Vol. 324, Issue 6092, pp. 70-3, (1986) (PubMed).
Aliases for IL-5 蛋白
interleukin 5 (IL5) 蛋白interleukin 5 (Il5) 蛋白
EDF 蛋白
IL-5 蛋白
Il-5 蛋白
IL5 蛋白
TRF 蛋白
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