Histone H2A Variant H2A.Z, Pht1 抗体

Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis. Plays an important role in maintaining a silenced chromatin state at centromeres and in the architecture of anaphase chromosomes. {ECO:0000269|PubMed:17947424, ECO:0000269|PubMed:19910462, ECO:0000269|PubMed:19915592}.