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Human Polyclonal CLDN4 Primary Antibody for IF (p), IHC (p) - ABIN680743
Wang, Chen, Liang, Yan, Lin, Liu, Luo, Huang, Li, Liu, Tang: Notch inhibition promotes fetal liver stem/progenitor cells differentiation into hepatocytes via the inhibition of HNF-1?. in Cell and tissue research 2014
Human Polyclonal CLDN4 Primary Antibody for ICC, IF - ABIN407633
Rho, Lampe: High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays. in Journal of proteome research 2013
Human Monoclonal CLDN4 Primary Antibody for FACS - ABIN4895293
Shim, Kim, Jin, Kim, Oh: Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptide-photosensitizer conjugate. in Acta pharmacologica Sinica 2017
these results suggest that Helicobacter pylori lipopolysaccharide induces TLR2 expression in the gastric adenocarcinoma cells, and that the longer the exposure to lipopolysaccharide, the greater the expression of TLR2 in the cell membrane; consequently the expression of claudin-4, -6, -7 and -9 also increases
HIF-1alpha (显示 HIF1A 抗体) expression was upregulated in the vasculogenic mimicry-positive CRC (显示 CALR 抗体) cell line HCT-116 and thereby affected the expression of the EMT (显示 ITK 抗体)-related markers Claudin-4, E-cadherin (显示 CDH1 抗体) (E-cd) and Vimentin(VIM (显示 VIM 抗体)).
expression of claudin-4 is highly specific for true epithelial differentiation and may be useful to distinguish SWI (显示 SMARCA1 抗体)/SNF (显示 SNRPA 抗体) complex-deficient undifferentiated carcinomas from sarcomas with epithelioid morphology. The lack of claudin-4 expression in ovarian small cell carcinomas of hypercalcemic type suggests that these tumors may be better regarded as sarcomas rather than carcinomas.
Data indiate a regulatory network in gastric cancer whereby claudin-4 expression is reduced by specific miRNAs, which are in turn bound by specific lncRNAs acting as competing endogenous RNAs (ceRNAs), resulting in increased claudin-4 expression.
This is the first study to show how TGF-beta (显示 TGFB1 抗体) regulates the expression of Claudin-4 through c-Jun (显示 JUN 抗体) signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells.
Claudin-4 functionally contributes to both ovarian tumor cell apoptosis resistance and migration and targeting extracellular loop interactions of claudin-4 may have therapeutic implications for reducing ovarian tumor burden.
Fluorescence-based flow cytometry and xenon magnetic resonance imaging (MRI (显示 C7ORF49 抗体)) indicate binding of the biosensor specifically to claudin 4 (Cldn4)-expressing cells.
Studies indicate that Grainyhead-like transcription factor 2 (显示 HNF1B 抗体) (GRHL2 (显示 GRHL2 抗体)) controls the expression of E-cadherin (CDH1 (显示 CDH1 抗体)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4) in tight junctions.
Studies indicate claudin 1 (CLDN-1 (显示 CLDN1 抗体)) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics.
Mislocalization claudin-3 (显示 CLDN3 抗体) to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.
Reg (显示 KCNH2 抗体) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
a Grhl2 (显示 GRHL2 抗体)/Ovol2 (显示 OVOL2 抗体) network controls Cldn4 and Rab25 (显示 RAB25 抗体) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Data show that claudin-4 and claudin-7 (显示 CLDN7 抗体) were observed in hepatocytes of severely damaged mouse and human livers.
The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (显示 PRSS8 抗体)).
Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice.
The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium.
the results indicate that Grhl2 (显示 GRHL2 抗体) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (显示 CLDN3 抗体) and Cldn4, as well as of Rab25 (显示 RAB25 抗体), which increases the Cldn4 protein and its localization at TJs
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3 (显示 CLDN3 抗体)/-4 protein suggests structural modifications of the toxin to target specific claudins
Claudin-3 (显示 CLDN3 抗体) in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes
Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.
Tumor necrosis factor-alpha (显示 TNF 抗体) increases claudin-1 (显示 CLDN1 抗体), 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.
Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells
These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.
This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
, Clostridium perfringens enterotoxin receptor 1
, Williams-Beuren syndrome chromosomal region 8 protein
, clostridium perfringens enterotoxin receptor
, tight junction-associated protein
, claudin 4