The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009].
Grönroos, Hellman, Heldin, Ericsson: "Control of Smad7 stability by competition between acetylation and ubiquitination." in: Molecular cell, Vol. 10, Issue 3, pp. 483-93, (2002) (PubMed).
Makowski, Dutnall, Annunziato: "Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase." in: The Journal of biological chemistry, Vol. 276, Issue 47, pp. 43499-502, (2001) (PubMed).
Cheung, Tanner, Cheung, Sassone-Corsi, Denu, Allis: "Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation." in: Molecular cell, Vol. 5, Issue 6, pp. 905-15, (2000) (PubMed).
Aliases for HAT1 抗体
histone acetyltransferase 1 (HAT1) 抗体 histone acetyltransferase 1 (Hat1) 抗体 histone acetyltransferase of the GNAT family 2 (HAG2) 抗体 histone acetyltransferase 1 (hat1) 抗体 histone acetyltransferase catalytic subunit (HAT1) 抗体 histone acetyltransferase Hat1 (hat1) 抗体 histone acetyltransferase 1 L homeolog (hat1.L) 抗体 HAC07 抗体 HAC7 抗体 hac106 抗体 HAG02 抗体 hat1 抗体 histone acetyltransferase of the GNAT family 2 抗体 KAT1 抗体 MIK19.19 抗体 MIK19_19 抗体 zgc:92639 抗体