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抗Human TGFBR1 抗体:
抗Mouse (Murine) TGFBR1 抗体:
抗Rat (Rattus) TGFBR1 抗体:
Human Polyclonal TGFBR1 Primary Antibody for IF (p), IHC (p) - ABIN671256
Xie, Chen, Miao, Tang, Fu: Regulation of cellular behaviors of fibroblasts related to wound healing by sol-gel derived bioactive glass particles. in Journal of biomedical materials research. Part A 2016
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Human Polyclonal TGFBR1 Primary Antibody for IHC (p), WB - ABIN392279
Miles, Tung, Aguiar, Kurtoglu, Sikes: Increased TGF-?1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling. in The Prostate 2012
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Human Polyclonal TGFBR1 Primary Antibody for ELISA, WB - ABIN563176
Matsunobu, Torigoe, Ishikawa, de Vega, Kulkarni, Iwamoto, Yamada: Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. in Developmental biology 2009
Mouse (Murine) Monoclonal TGFBR1 Primary Antibody for FACS - ABIN4896299
Bodogai, Moritoh, Lee-Chang, Hollander, Sherman-Baust, Wersto, Araki, Miyoshi, Yang, Trinchieri, Biragyn: Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells. in Cancer research 2015
Human Polyclonal TGFBR1 Primary Antibody for IF, WB - ABIN317892
Yu, Hu, Yang, Takemori, Li, Zheng, Hong, Liao, Wen: Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway. in International journal of molecular medicine 2013
ALK5 is an important mediator of HTFs fibrosis. ALK5 is a potential therapeutic target to suppress scar formation after filtration surgery.
PAR2 (显示 F2RL1 抗体) is crucial for TGF-beta1 (显示 TGFB1 抗体)-induced cell motility by its ability to sustain expression of ALK5. Therapeutically targeting PAR2 (显示 F2RL1 抗体) may thus be a promising approach in preventing TGF-beta (显示 TGFB1 抗体)-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types.
results suggest a role for prostatic expression of TGF-B, IL-1a (显示 IL1A 抗体), TGFBRI and TGFBRII as prognostic markers for prostate cancer. The rational combination of novel agents directed toward the inactivation of TGF-B, IL-1a (显示 IL1A 抗体), TGFBRI and TGFBRII could disrupt complementary tumor cell proliferation pathways.
Data show that twist-related protein 1 (Twist1 (显示 TWIST1 抗体)) requires TGF-beta type-I receptor (TGFBR1)-activation for activation for epithelial-mesenchymal transition (EMT (显示 ITK 抗体))-induction.
This study shows that TFAP2C (显示 TFAP2C 抗体) promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 (显示 PAK1 抗体) signaling.
combined inhibition of ALK5 and CTGF (显示 CTGF 抗体) is required to prevent TGFbeta (显示 TGFB1 抗体)-induced nodule formation in tri (显示 VANGL2 抗体)-cellular cultures
Aortic diseases in patients with TGFBR1 or TGFBR2 (显示 TGFBR2 抗体) mutations show the same prevalence of systemic features and the same global survival.
Results show that TGFBR1 expression is regulated in bladder cancer cell through its desumoylation by SENP2.
Low TGFBR1 expression is associated with oral cancer progression.
TGF-beta (显示 TGFB1 抗体) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset preeclampsia. Endoglin (显示 ENG 抗体) was increased in both subtypes.
The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.
Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
TGFbeta (显示 TGFB1 抗体) is abundant in boar seminal plasma, thus TGFbeta (显示 TGFB1 抗体) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.
Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.
isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.
Results show that ALK5 and ALK1 (显示 ACVRL1 抗体) play antagonistic roles in TGF-beta (显示 TGFB1 抗体)-induced podosome formation in aortic endothelial cells.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (显示 ACVRL1 抗体) and ALK5 interact with heat shock protein 90 (显示 HSP90 抗体).
GM-CSF (显示 CSF2 抗体) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (显示 TGFB1 抗体) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (显示 TGFB1 抗体) by the same ASMC; corticosteroids were inhibitory
ALK5 and Smad4 (显示 SMAD4 抗体) have roles in TGF-beta1 (显示 TGFB1 抗体)-induced pulmonary endothelial permeability
These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (显示 TGFB1 抗体) responsiveness.
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.
TGF-beta1 (显示 TGFB1 抗体) downregulates caveolin-1 (显示 CAV1 抗体) of cultured endothelial cells, involving ALK-5 receptor subtype
Deletion of smooth muscle cell-specific Tgfbr1 inhibits arterial neointimal hyperplasia in short term, but promotes an undesired vascular phenotype for injured arteries.
TGFbetaR1 signalling is needed for development of CD103 (显示 ITGAE 抗体)(+)CD11b (显示 ITGAM 抗体)(+) intestinal DCs from CD103 (显示 ITGAE 抗体)(-)CD11b (显示 ITGAM 抗体)(+) cells and that they contribute to the generation of Th17 and regulatory T cells.
Overactivation of TGFBR1 drives gonadal tumor development. The TGFBR1 constitutively active mouse model phenocopies a number of morphological, hormonal, and molecular features of human granulosa cell tumors and are potentially valuable for preclinical testing of targeted therapies to treat granulosa cell tumors, a class of poorly defined ovarian malignancies.
results indicate that CD34 (显示 CD34 抗体)+ cells and signaling through ALK5 play pivotal roles in the morphogenesis of interstitial-like, peritubular-like and cord-like structures
a novel role for SREBP-1 (显示 SREBF1 抗体) as a cell surface retention factor for TbetaRI in mesangial cells, is reported.
a surface population of Hsp90 (显示 HSP90 抗体) extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta (显示 TGFB1 抗体)-activated fibroblasts.
Conditional deletion of Tgfbr1 in PTEN (显示 PTEN 抗体)-inactivated endometrium leads to a disease that recapitulates invasive and lethal human endometrial cancer.
fluid shear stress induces autocrine TGF-beta (显示 TGFB1 抗体)/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (显示 MAP2K1 抗体)/2-mediated signaling.
both GDF-15 (显示 GDF15 抗体) and TGF-beta1 (显示 TGFB1 抗体) counteract chemokine (显示 CCL1 抗体)-induced integrin activation on neutrophils via the ALK-5/TGF-betaRII heterodimer.
CD109 (显示 CD109 抗体) differentially regulates TGF-beta (显示 TGFB1 抗体)-induced ALK1 (显示 ACVRL1 抗体)-Smad1 (显示 SMAD1 抗体)/5 versus ALK5-Smad2 (显示 SMAD2 抗体)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (显示 CD109 抗体) expression regulates dermal function through a paracrine mechanism
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
TGF-beta receptor type I
, TGF-beta receptor type-1
, TGF-beta type I receptor
, activin A receptor type II-like kinase, 53kD
, activin A receptor type II-like kinase, 53kDa
, activin A receptor type II-like protein kinase of 53kD
, activin receptor-like kinase 5
, serine/threonine-protein kinase receptor R4
, transforming growth factor beta receptor I
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
, transforming growth factor-beta receptor type I
, transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor beta type I receptor
, transforming growth factor, beta receptor 1
, transforming growth factor beta receptor 1
, activin A receptor type II-like kinase
, transforming growth factor beta receptor type I
, transforming growth factor beta, receptor 1
, type I serine/threonine kinase receptor
, TGF-beta receptor type-1-like
, transforming growth factor, beta receptor I