This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Aug 2010].
Noutsou, Li, Ling, Jones, Wang, Chen, Sen: "The Cohesin Complex Is Necessary for Epidermal Progenitor Cell Function through Maintenance of Self-Renewal Genes." in: Cell reports, Vol. 20, Issue 13, pp. 3005-3013, (2018) (PubMed).
Darido, Georgy, Wilanowski, Dworkin, Auden, Zhao, Rank, Srivastava, Finlay, Papenfuss, Pandolfi, Pearson, Jane: "Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis." in: Cancer cell, Vol. 20, Issue 5, pp. 635-48, (2011) (PubMed).
Yu, Mannik, Soto, Lin, Andersen: "The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation." in: The EMBO journal, Vol. 28, Issue 13, pp. 1890-903, (2009) (PubMed).
Ting, Wilanowski, Cerruti, Zhao, Cunningham, Jane: "The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors." in: The Biochemical journal, Vol. 370, Issue Pt 3, pp. 953-62, (2003) (PubMed).