The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Zeng, Yang, Hu, Liu, Yang, Ran, Li, Li, Yu: "Grb7 gene amplification and protein expression by FISH and IHC in ovarian cancer." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 11296-304, (2016) (PubMed).
Vayssière, Zalcman, Mahé, Mirey, Ligensa, Weidner, Chardin, Camonis: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family." in: FEBS letters, Vol. 467, Issue 1, pp. 91-6, (2000) (PubMed).
Tanaka, Mori, Akiyoshi, Tanaka, Mafune, Wands, Sugimachi: "A novel variant of human Grb7 is associated with invasive esophageal carcinoma." in: The Journal of clinical investigation, Vol. 102, Issue 4, pp. 821-7, (1998) (PubMed).
Margolis, Silvennoinen, Comoglio, Roonprapunt, Skolnik, Ullrich, Schlessinger: "High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 19, pp. 8894-8, (1992) (PubMed).
Aliases for GRB7 抗体
growth factor receptor bound protein 7 (GRB7) 抗体 growth factor receptor bound protein 7 (Grb7) 抗体 GRB7 抗体 mKIAA4028 抗体