抗Rat (Rattus) 抗体:
抗Mouse (Murine) 抗体:
Recombinant 3-OST-5 only exhibited sulfotransferase activity toward heparan sulfate and heparin. 3-OST-5 was highly expressed in fetal brain, followed by adult brain and spinal cord, and at very low or undetectable levels in other tissues.
Results demonstrate that the human 3-O-sulfotransferase isoform 5 gene is capable of synthesizing anticoagulant heparan sulfate (HS) in CHO cells and may contribute to the biosynthesis of HS in humans.
Structural analysis of 3-OST-5 HS(act) revealed that the antithrombin-binding site of 3-OST-5 HS(act) is located within a domain clustered with N-sulfated glucosamine units.
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 22.214.171.124) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003
, heparan sulfate 3-O-sulfotransferase 5
, heparan sulfate 3-OST-5
, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
, heparan sulfate glucosamine 3-O-sulfotransferase 5
, heparan sulfate (glucosamine) 3-O-sulfotransferase 6
, heparan sulfate glucosamine 3-O-sulfotransferase 6
, heparan sulfate (glucosamine) 3-O-sulfotransferase 5