This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008].
Tomilov, Bettaieb, Kim, Sahdeo, Tomilova, Lam, Hagopian, Connell, Fong, Rowland, Griffey, Ramsey, Haj, Cortopassi: "Shc depletion stimulates brown fat activity in vivo and in vitro." in: Aging cell, Vol. 13, Issue 6, pp. 1049-58, (2014) (PubMed).
Kathiresan, Melander, Guiducci, Surti, Burtt, Rieder, Cooper, Roos, Voight, Havulinna, Wahlstrand, Hedner, Corella, Tai, Ordovas, Berglund, Vartiainen, Jousilahti, Hedblad, Taskinen, Newton-Cheh et al.: "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. ..." in: Nature genetics, Vol. 40, Issue 2, pp. 189-97, (2008) (PubMed).
Veiga-da-Cunha, Delplanque, Gillain, Bonthron, Boutin, Van Schaftingen, Froguel: "Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians." in: Diabetologia, Vol. 46, Issue 5, pp. 704-11, (2003) (PubMed).