FZR1 抗体
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
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Latest Publications for our FZR1 抗体
: "APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion." in: Cellular and molecular neurobiology, Vol. 39, Issue 1, pp. 123-135, (2019) (PubMed).: "Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 19, pp. 9423-9432, (2019) (PubMed).
: "Inhibition of neddylation causes meiotic arrest in mouse oocyte." in: Cell cycle (Georgetown, Tex.), Vol. 18, Issue 11, pp. 1254-1267, (2019) (PubMed).
: "G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 31, Issue 7, pp. 2925-2936, (2017) (PubMed).
: "Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival." in: Scientific reports, Vol. 6, pp. 31158, (2016) (PubMed).
: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." in: Molecular pain, Vol. 12, (2016) (PubMed).
: "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway." in: Nature communications, Vol. 5, pp. 3480, (2014) (PubMed).
Aliases for FZR1 抗体
fizzy and cell division cycle 20 related 1 (Fzr1) 抗体fizzy/cell division cycle 20 related 1 (CDH1-C) 抗体
fizzy and cell division cycle 20 related 1 (FZR1) 抗体
fizzy-related protein homolog (LOC100027495) 抗体
fizzy-related protein homolog (LOC100179951) 抗体
fizzy/cell division cycle 20 related 1 (Drosophila) (Fzr1) 抗体
fizzy/cell division cycle 20 related 1a (fzr1a) 抗体
AW108046 抗体
CDC20C 抗体
CDH1 抗体
Cdh1 抗体
CDH1-C 抗体
FYR 抗体
Fyr 抗体
FZR 抗体
fzr1 抗体
FZR2 抗体
HCDH 抗体
HCDH1 抗体
zgc:55450 抗体
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