FLT3 抗体
(Fms-Related tyrosine Kinase 3 (FLT3))
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008].
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FLT3
适用: 人
FACS
宿主: 小鼠
Monoclonal
BV10(BV10A4)
Elab Fluor®Violet 450
Latest Publications for our FLT3 抗体
: "A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling." in: Leukemia, Vol. 27, Issue 12, pp. 2301-10, (2013) (PubMed).
: "Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 8, pp. 3822-30, (2012) (PubMed).
: "Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia." in: Cancer, Vol. 118, Issue 24, pp. 6110-7, (2012) (PubMed).
: "Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia." in: Blood, Vol. 120, Issue 15, pp. 3069-79, (2012) (PubMed).
: "Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits." in: Differentiation; research in biological diversity, Vol. 82, Issue 3, pp. 153-64, (2011) (PubMed).
: "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 10918-29, (2011) (PubMed).
: "A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8126-34, (2008) (PubMed).
: "Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling." in: British journal of haematology, Vol. 141, Issue 4, pp. 483-93, (2008) (PubMed).
: "Incorporating FLT3 inhibitors into acute myeloid leukemia treatment regimens." in: Leukemia & lymphoma, Vol. 49, Issue 5, pp. 852-63, (2008) (PubMed).
: "Soluble phosphorylated fms-like tyrosine kinase III. FLT3 protein in patients with acute myeloid leukemia (AML)." in: Leukemia research, Vol. 31, Issue 6, pp. 791-7, (2007) (PubMed).
: "Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 8, pp. 3822-30, (2012) (PubMed).
: "Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia." in: Cancer, Vol. 118, Issue 24, pp. 6110-7, (2012) (PubMed).
: "Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia." in: Blood, Vol. 120, Issue 15, pp. 3069-79, (2012) (PubMed).
: "Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits." in: Differentiation; research in biological diversity, Vol. 82, Issue 3, pp. 153-64, (2011) (PubMed).
: "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 10918-29, (2011) (PubMed).
: "A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8126-34, (2008) (PubMed).
: "Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling." in: British journal of haematology, Vol. 141, Issue 4, pp. 483-93, (2008) (PubMed).
: "Incorporating FLT3 inhibitors into acute myeloid leukemia treatment regimens." in: Leukemia & lymphoma, Vol. 49, Issue 5, pp. 852-63, (2008) (PubMed).
: "Soluble phosphorylated fms-like tyrosine kinase III. FLT3 protein in patients with acute myeloid leukemia (AML)." in: Leukemia research, Vol. 31, Issue 6, pp. 791-7, (2007) (PubMed).
Aliases for FLT3 抗体
fms related tyrosine kinase 3 (FLT3) 抗体FMS-like tyrosine kinase 3 (Flt3) 抗体
fms-related tyrosine kinase 3 (Flt3) 抗体
fms related tyrosine kinase 3 (Flt3) 抗体
B230315G04 抗体
CD135 抗体
Flk-2 抗体
FLK-2 抗体
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FLK2 抗体
Flt-3 抗体
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