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F2RL1 产品

(Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1))
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008].

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Featured F2RL1 Categories

F2RL1 抗体

High quality antibodies with extensive validation data.

F2RL1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

F2RL1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended F2RL1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF, ICC
Validations
  • (5)
Cat. No. ABIN7043075
Quantity 25 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN1049232
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN1683023
Quantity 100 μg
Datasheet Datasheet

Recommended F2RL1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (6)
  • (1)
Cat. No. ABIN6954858
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965879
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965880
Quantity 96 tests
Datasheet Datasheet

Recommended F2RL1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122416
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353314
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3113973
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our F2RL1 Products

Klinngam, Fu, Janga, Edman, Hamm-Alvarez: "Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells." in: International journal of molecular sciences, Vol. 19, Issue 11, (2019) (PubMed).

Cheng, Fiez-Vandal, Schlenker, Edman, Aggeler, Brown, Brown, Cooke, Dumelin, Doré, Geschwindner, Grebner, Hermansson, Jazayeri, Johansson, Leong, Prihandoko, Rappas, Soutter, Snijder, Sundström et al.: "Structural insight into allosteric modulation of protease-activated receptor 2. ..." in: Nature, Vol. 545, Issue 7652, pp. 112-115, (2017) (PubMed).

Quanjun, Qingyu, Qiliang, Liqun, Jinmei, Ziquan, Shike: "Effect and mechanism of PAR-2 on the proliferation of esophageal cancer cells." in: European review for medical and pharmacological sciences, Vol. 20, Issue 22, pp. 4688-4696, (2017) (PubMed).

Kouzaki, Matsumoto, Kato, Tojima, Shimizu, Shimizu: "Epithelial Cell-Derived Cytokines Contribute to the Pathophysiology of Eosinophilic Chronic Rhinosinusitis." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 36, Issue 3, pp. 169-79, (2016) (PubMed).

Pan, Zhang, Zang, Tan, Jin: "Hydroxysafflor yellow A inhibits TGF-β1-induced activation of human fetal lung fibroblasts in vitro." in: The Journal of pharmacy and pharmacology, Vol. 68, Issue 10, pp. 1320-30, (2016) (PubMed).

Rohan, Smetakova, Kukal, Rusina, Matej: "Proteinase-activated receptor 2 and disease biomarkers in cerebrospinal fluid in cases with autopsy-confirmed prion diseases and other neurodegenerative diseases." in: BMC neurology, Vol. 15, pp. 50, (2015) (PubMed).

Viodé, Lejeune, Turlier, Rouquier, Casas, Mengeaud, Redoulès, Schmitt: "Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation." in: Experimental dermatology, Vol. 23, Issue 4, pp. 274-5, (2014) (PubMed).

Mat?j, Sm?táková, Vašáková, Nováková, Sterclová, Kukal, Olejár: "PAR-2, IL-4R, TGF-? and TNF-? in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis." in: Experimental and therapeutic medicine, Vol. 8, Issue 2, pp. 533-538, (2014) (PubMed).

Vasakova, Sterclova, Stranska, Mandakova, Skibova, Matej: "Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias." in: The open respiratory medicine journal, Vol. 6, pp. 160-4, (2013) (PubMed).

Yau, Liu, Fairlie: "Toward drugs for protease-activated receptor 2 (PAR2)." in: Journal of medicinal chemistry, Vol. 56, Issue 19, pp. 7477-97, (2013) (PubMed).

Synonyms and alternative names related to F2RL1

Proteinase-activated receptor 2 (par2), F2R like trypsin receptor 1 (F2RL1), coagulation factor II (thrombin) receptor-like 1 (F2rl1), F2R like trypsin receptor 1 (F2rl1), Gpcr11, GPR11, PAR-2, Par-2, par2, PAR2, Par2

Protein level used designations for F2RL1

  • Proteinase-activated receptor 2
  • G-protein coupled receptor 11
  • coagulation factor II receptor-like 1
  • protease-activated receptor 2
  • proteinase-activated receptor 2
  • thrombin receptor-like 1
  • Protease-activated receptor-2
  • proteinase-activated receptor-2
  • Proteinase-activated receptor-2 G protein-coupled receptor 11
  • Proteinase-activated receptor-2, G protein-coupled receptor 11
  • PAR-2
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