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EXOSC4 产品

(Exosome Component 4 (EXOSC4))

Categories

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity).

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Featured EXOSC4 Categories

EXOSC4 抗体

High quality antibodies with extensive validation data.

EXOSC4 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended EXOSC4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet

Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN202117
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN527098
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7247624
Quantity 200 μL
Datasheet Datasheet

Recommended EXOSC4 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6204238
Quantity 96 tests
Datasheet Datasheet

Recommended EXOSC4 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353242
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353240
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3092480
Quantity 1 mg
Datasheet Datasheet

Synonyms and alternative names related to EXOSC4

exosome component 4 (exosc4), exosome component 4 (EXOSC4), exosome component 4 (CC1G_03561), exosome component 4 S homeolog (exosc4.S), exosome component 4 (Exosc4), 1110039I09Rik, 1500001N04Rik, EXOSC4, hRrp41p, p12A, RRP41, Rrp41, RRP41A, Rrp41p, SKI6, Ski6p, zgc:73175

Protein level used designations for EXOSC4

  • exosome component 4
  • exosome complex component RRP41
  • exosome complex exonuclease RRP41
  • exosome component Rrp41
  • ribosomal RNA-processing protein 41
  • ribosomal RNA processing protein 41
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