RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi.
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Yang, Purdy, Marzluff, Dominski: "Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA." in: The Journal of biological chemistry, Vol. 281, Issue 41, pp. 30447-54, (2006) (PubMed).
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