DUSP6 抗体
(Dual Specificity Phosphatase 6 (DUSP6))
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Verified
DUSP6
适用: 人, 小鼠, 大鼠, Pig
WB, ELISA
宿主: 山羊
Polyclonal
unconjugated
1 image
DUSP6
适用: 人, 小鼠, 大鼠
WB, ELISA, IHC, IF
宿主: 兔
Polyclonal
unconjugated
1 image
Latest Publications for our DUSP6 抗体
: "Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6." in: Hepatology (Baltimore, Md.), (2015) (PubMed).: "TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 12, pp. 1107-20, (2014) (PubMed).
: "Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 167, Issue 1, pp. 93-101, (2012) (PubMed).
: "Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of ..." in: The Journal of biological chemistry, Vol. 286, Issue 29, pp. 25663-74, (2011) (PubMed).
: "Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis." in: The American journal of pathology, Vol. 175, Issue 2, pp. 867-81, (2009) (PubMed).
: "Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 290, Issue 4, pp. H1587-95, (2006) (PubMed).
: "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer." in: Journal of human genetics, Vol. 50, Issue 4, pp. 159-67, (2005) (PubMed).
: "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 8, pp. 1034-42, (2005) (PubMed).
: "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41882-91, (2004) (PubMed).
: "Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer." in: Cytogenetics and cell genetics, Vol. 82, Issue 3-4, pp. 156-9, (1999) (PubMed).
Aliases for DUSP6 抗体
dual specificity phosphatase 6 (DUSP6) 抗体dual specificity phosphatase 6 (Dusp6) 抗体
dual specificity phosphatase 6 (dusp6) 抗体
dual specificity phosphatase 6 L homeolog (dusp6.L) 抗体
Dual specificity protein phosphatase 6 (dus6) 抗体
1300019I03Rik 抗体
DUSP6 抗体
dusp6 抗体
HH19 抗体
MKP-3 抗体
MKP3 抗体
Mkp3 抗体
mkp3 抗体
PYST1 抗体
pyst1 抗体
wu:fd99d09 抗体
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