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Human Polyclonal XRCC4 Primary Antibody for IHC - ABIN967264
Li, Otevrel, Gao, Cheng, Seed, Stamato, Taccioli, Alt: The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. in Cell 1996
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Human Polyclonal XRCC4 Primary Antibody for IHC - ABIN967265
Leber, Wise, Mizuta, Meek: The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. in The Journal of biological chemistry 1998
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Human Polyclonal XRCC4 Primary Antibody for ICC, IF - ABIN4366467
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
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Human Polyclonal XRCC4 Primary Antibody for IF, IHC (p) - ABIN1327721
Enervald, Du, Visnes, Björkman, Lindgren, Wincent, Borck, Colleaux, Cormier-Daire, van Gent, Pie, Puisac, de Miranda, Kracker, Hammarström, de Villartay, Durandy, Schoumans, Ström, Pan-Hammarström: A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination. in The Journal of experimental medicine 2013
Human Polyclonal XRCC4 Primary Antibody for ICC, IF - ABIN440923
van Sluis, McStay: A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. in Genes & development 2015
Mouse (Murine) Polyclonal XRCC4 Primary Antibody for IHC, WB - ABIN3022382
Dong, Wang, Wang, Zhang, Zhu, Gao, Yang, Qin, Liang, Chen, Deng, Ning, Liang, Gao, Xu: A stress-induced cellular aging model with postnatal neural stem cells. in Cell death & disease 2014
XRCC4 has a negative role in Agrobacterium T-DNA integration.
Three-locus model of gene-gene interactions OGG1 (显示 OGG1 抗体) (rs1052133) * ADPRT (显示 PARP1 抗体) (rs1136410) * XRCC4 (rs6869366) was associated with high genotoxic risk in coal miners.
Results showed that eNOS (显示 NOS3 抗体) and XRCC4 VNTR variants might play a potential role in schizophrenia + nicotine dependence and/or nicotine dependence pathophysiology.
Phospho-blocking and -mimicking mutations impact both the stability and DNA bridging capacity of XRCC4/XLF (显示 NHEJ1 抗体) complexes, but without affecting their ability to stimulate LIG4 (显示 LIG4 抗体) activity. Implicit in this finding is that phosphorylation may regulate DNA bridging by XRCC4/XLF (显示 NHEJ1 抗体) filaments.
This study demonstrated both ligase IV and XRCC4 may act in concert to modulate the development of glioma.
Data suggest that genetic variants of XRCC4 and ERCC1 (显示 ERCC1 抗体) may independently or jointly affect survival in chemotherapy-treated gastric cancer (GCa (显示 NPR1 抗体)) patients by modulating the gene expression in the tumors.
In a recombinant PNKP (显示 PNKP 抗体)-XRCC4-LigIV complex, stable binding of PNKP (显示 PNKP 抗体) requires XRCC4 phosphorylation. Only one PNKP (显示 PNKP 抗体) protomer binds per XRCC4 dimer. Both the PNKP (显示 PNKP 抗体) FHA (显示 CRY2 抗体) and catalytic domains contact the XRCC4 coiled-coil and LigIV BRCT repeats. Multipoint contacts between PNKP (显示 PNKP 抗体) and XRCC4-LigIV regulate PNKP (显示 PNKP 抗体) recruitment and activity within NHEJ.
Data suggest that stimulation of Artemis nuclease/DCLRE1C (显示 DCLRE1C 抗体) activity by XRCC4-DNA ligase IV (显示 LIG4 抗体) hetero-complex and efficiency of blunt-end ligation are determined by structural configurations at the DNA ends. (XRCC4 = X-ray repair cross complementing 4)
involvement of ZNF281 (显示 ZNF281 抗体) in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
the various XRCC4 mutations that lead to primordial dwarfism and their impact on non-homologous end joining and V(D)J recombination are discussed (Review)
XRCC4 expression might have an influence on results of radiotherapy for patients with esophageal squamous cell carcinoma.
We find that non-canonical HR termination can occur in the absence of the classical non-homologous end joining gene XRCC4. We observe obligatory use of microhomology (MH)-mediated end joining and/or nucleotide addition during rejoining with the second end of the break
Data show that combined deletion of X-ray repair cross-complementing protein 4 (Xrcc4) and tumor suppressor p53 (Trp53 (显示 TP53 抗体)) predisposes B cells to lymphomagenesis.
FBXW7 (显示 FBXW7 抗体) facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 in tumor cells.
The present results collectively indicated that Lys271, but not Lys210, of XRCC4 is required for the nuclear localization of XRCC4 and LIG4 (显示 LIG4 抗体) and that the nuclear localizing ability is essential for DSB repair function of XRCC4.
DNA-PK and ATM (显示 ATM 抗体) acts in parallel upstream of XRCC4, regulating through phosphorylation
XRCC4 C-terminal point mutants, R325F and N326L, are functionally deficient in terms of cell survival after irradiation.
These results establish that nonrecurrent CNVs can be, and frequently are, formed by mechanisms other than Xrcc4-dependent NHEJ.
analysis of the association of radiation-induced XRCC4 with chromatin DNA, by biochemical fractionation
conditional inactivation of the XRCC4 in nestin (显示 NES 抗体)-expressing neuronal progenitor cells, although leading to no obvious phenotype in a WT background, leads to early onset of neuronally differentiated medulloblastomas (MBs (显示 NEU2 抗体)) in a p53 (显示 TP53 抗体)-deficient background
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.
DNA repair protein XRCC4
, X-ray repair complementing defective repair in Chinese hamster cells 4
, DNA-repair protein XRCC4
, X-ray repair cross complementing protein 4
, X-ray repair cross-complementing protein 4
, X-ray repair, complementing defective, repair in Chinese hamster