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抗Rat (Rattus) 抗体:
Human Polyclonal PARP2 Primary Antibody for ChIP, IP - ABIN2668807
Hanzlikova, Gittens, Krejcikova, Zeng, Caldecott: Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin. in Nucleic acids research 2016
Human Polyclonal PARP2 Primary Antibody for ELISA, WB - ABIN250990
Kofler, Otsuka, Zhang, Noppens, Grafe, Koh, Dawson, de Murcia, Hurn, Traystman: Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005
Human Polyclonal PARP2 Primary Antibody for WB - ABIN151360
Ovadje, Ammar, Guerrero, Arnason, Pandey: Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. in Oncotarget 2016
data further suggest that ARTD2 would function in double strand break repair as a dimeric module, while in single strand break repair it would function as a monomer.
Report a requirement for PARP2 in stabilizing replication forks that encounter base excision repair (BER) intermediates through Fbh1 (显示 FBXO18 抗体)-dependent regulation of Rad51 (显示 RAD51 抗体). Whereas PARP2 is dispensable for tolerance of cells to single stranded breaks or homologous recombination dysfunction, it is redundant with PARP1 (显示 PARP1 抗体) in BER.
PARP2 specifically limits the accumulation of the resection barrier factor 53BP1 (显示 TP53BP1 抗体) at DNA damage sites, allowing efficient CtIP (显示 RBBP8 抗体)-dependent DNA end-resection
either PARP1 (显示 PARP1 抗体) or PARP2 are sufficient for near-normal XRCC1 (显示 XRCC1 抗体) recruitment at oxidative single-strand breaks
Studies indicate that poly(ADP-ribose) polymerase 2 (PARP2) is involved in the differentiation of several cell types, including erythrocytes, T cells and adipocytes.
Findings indicate that Increased poly(ADP-ribose) polymerase-2 (PARP-2) expression and loss of micrRNA miR (显示 MLXIP 抗体)-149 expression are involved in the pathogenesis of hepatocellular carcinomas (HCC (显示 FAM126A 抗体)) and are poor prognosis factors in patients with HCC (显示 FAM126A 抗体).
Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (显示 PARP1 抗体)/2 and tankyrase 1 (显示 TNKS 抗体)/2 inhibitor which has the advantage of targeting Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling addicted tumors.
The initial affinity between the PARP1 (显示 PARP1 抗体), PARP2 and the DNA damaged site appears to influence both the size of the Poly(ADP-Ribose) synthesized and the time of residence of PARylated PARP1 (显示 PARP1 抗体) and PARP2 on DNA damages.
Our data suggest for the first time that a SNP in PARP2, rs878156, may together with other genetic variants modulate cancer specific survival in breast cancer patients depending on chemotherapy
Our study differentiates the functions of PARP-2 domains from those of PARP-1 (显示 PARP1 抗体), the other major DDR (显示 DDR1 抗体)-PARP (显示 COL11A2 抗体), and highlights the specialization of the multi-domain architectures of DDR (显示 DDR1 抗体)-PARPs.
Peripheral T-cell number was not affected in single PARP-2-deficient mice. Double-deficiency in PARP-1/PARP-2 in T-cells led to highly aggressive T-cell lymphomas.
PARP2 protein deficiency protected mice from Concanavalin A -induced Liver Damage.
Activation of either PARP-1 (显示 PARP1 抗体) or -2 is likely to play a role in muscle protein catabolism via oxidative stress, NF-kappaB (显示 NFKB1 抗体) signaling, and enhanced proteasomal degradation in cancer-induced cachexia.
PARP1 (显示 PARP1 抗体)/2 inhibitor simmiparib causes growth inhibition in cancer cell- or tissue-derived xenografts in nude mice.
The findings highlight specific non-overlapping functions of PARP1 (显示 PARP1 抗体) and PARP2 at H2AX (显示 H2AFX 抗体)-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 (显示 PARP1 抗体) in nonhomologous end-joining-deficient cells.
Data show reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 (显示 PARP1 抗体) and PARP-2 knockout mice.
PARP-2 has an essential role in erythropoiesis by limiting replicative stress in erythroid progenitors.
PARP-1 (显示 PARP1 抗体) and -2 play a role in cancer-induced cachexia, thus selective pharmacological inhibition of PARP-1 (显示 PARP1 抗体) and -2 may be of interest in clinical settings
the depletion of PARP-2 leads to lower HDL (显示 HSD11B1 抗体) levels which represent a risk factor to cardiovascular diseases.
This study represents the first description of a significant role for PARP-2 in neuroinflammation and neurological dysfunction in Experimental autoimmune encephalomyelitis
We found that larger deletions of >20 bp predominated after DSB repair in ku80 (显示 XRCC5 抗体) and ku80 (显示 XRCC5 抗体) parp1 parp2 mutants, corroborating with a role of KU in preventing DSB end resection. Deletion lengths did not significantly differ between ku80 (显示 XRCC5 抗体) and ku80 (显示 XRCC5 抗体) parp1 parp2 mutants, suggesting that a KU- and PARP (显示 PARP1 抗体)-independent b-NHEJ mechanism becomes active in these mutants.
we have found that although plant PARPs and PARGs have partially overlapping functions Arabidopsis PARP2 and PARG1 play the predominant roles in plant poly(ADP-ribosyl)ation during DNA damage and immune responses.
whilst all isoforms of PARP (显示 PARP1 抗体) were localized to the nucleus they are also present in non-nuclear locations with parp1 and parp3 (显示 PARP3 抗体) also localised in the cytosol, and parp2 also present in the mitochondria
Studies indicate that a massive and rapid accumulation of a massive and rapid accumulation poly(ADP-ribose) polymerases AtPARP1 and AtPARP2 transcripts was observed upon treatment with ionizing radiation and reactive oxigen species (ROS (显示 ROS1 抗体)).
Poly(ADP-ribose)polymerase (显示 PARP1 抗体) activity controls plant growth by promoting leaf cell number.
Evidence suggests a link between the glutathione pool and PARP (显示 PARP1 抗体) expression and activity that is perhaps related to the distribution of intracellular glutathione between the cytoplasm and the nucleus. [PARP2]
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2
, ADP-ribosyltransferase diphtheria toxin-like 2
, NAD(+) ADP-ribosyltransferase 2
, poly (ADP-ribose) polymerase family, member 2
, poly (ADP-ribosyl) transferase-like 2
, poly [ADP-ribose] polymerase 2
, poly(ADP-ribose) synthetase
, poly[ADP-ribose] synthase 2
, poly[ADP-ribose] synthetase 2
, ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2
, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2
, poly (ADP-ribose) polymerase 2
, poly [ADP-ribose] polymerase 2-like
, Poly[ADP-ribose] synthase 2