This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008].
Bodmer, Eleveld, Kater-Baats, Janssen, Janssen, Weterman, Schoenmakers, Nickerson, Linehan, Zbar, van Kessel: "Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21)." in: Human molecular genetics, Vol. 11, Issue 6, pp. 641-9, (2002) (PubMed).
Bodmer, Janssen, Jonkers, van den Berg, Dijkhuizen, Debiec-Rychter, Schoenmakers, van Kessel: "Molecular cytogenetic analysis of clustered sporadic and familial renal cell carcinoma-associated 3q13 approximately q22 breakpoints." in: Cancer genetics and cytogenetics, Vol. 136, Issue 2, pp. 95-100, (2002) (PubMed).
Aliases for DIRC2 抗体
disrupted in renal carcinoma 2 (DIRC2) 抗体 disrupted in renal carcinoma 2 L homeolog (dirc2.L) 抗体 disrupted in renal carcinoma 2 (dirc2) 抗体 disrupted in renal carcinoma 2 (Dirc2) 抗体 disrupted in renal carcinoma 2 (human) (Dirc2) 抗体 MGC69320 抗体 MGC80843 抗体 rcc4 抗体 RCC4 抗体 zgc:92095 抗体