DIO3 抗体
(Deiodinase, Iodothyronine, Type III (DIO3))
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008].
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Latest Publications for our DIO3 抗体
: "Reduced Skeletal Muscle Protein Turnover and Thyroid Hormone Metabolism in Adaptive Thermogenesis That Facilitates Body Fat Recovery During Weight Regain." in: Frontiers in endocrinology, Vol. 10, pp. 119, (2019) (PubMed).: "Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes." in: JCI insight, Vol. 4, Issue 18, (2019) (PubMed).
: "A thyroid hormone network exists in synovial fibroblasts of rheumatoid arthritis and osteoarthritis patients." in: Scientific reports, Vol. 9, Issue 1, pp. 13235, (2019) (PubMed).
: "Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans." in: Endocrine, Vol. 59, Issue 2, pp. 353-363, (2018) (PubMed).
: "Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding." in: Frontiers in physiology, Vol. 6, pp. 254, (2015) (PubMed).
: "Thyroid hormone inactivation in gastrointestinal stromal tumors." in: The New England journal of medicine, Vol. 370, Issue 14, pp. 1327-34, (2014) (PubMed).
: "Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis." in: Endocrinology, Vol. 155, Issue 10, pp. 4061-8, (2014) (PubMed).
: "Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis." in: Endocrinology, Vol. 155, Issue 8, pp. 3160-71, (2014) (PubMed).
: "Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity." in: The Biochemical journal, Vol. 453, Issue 1, pp. 71-82, (2013) (PubMed).
: "Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 44, pp. 17232-46, (2013) (PubMed).
Aliases for DIO3 抗体
iodothyronine deiodinase 3 (DIO3) 抗体deiodinase, iodothyronine, type 3 (dio3) 抗体
deiodinase, iodothyronine, type III (dio3) 抗体
deiodinase, iodothyronine type III (Dio3) 抗体
deiodinase, iodothyronine, type 3 L homeolog (dio3.L) 抗体
iodothyronine deiodinase 3 (Dio3) 抗体
5DIII 抗体
D3 抗体
DIOIII 抗体
dioiii 抗体
itdi3 抗体
txdi3 抗体
TXDI3 抗体
XL-15 抗体
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