Deoxyuridine Triphosphatase 产品
(Deoxyuridine Triphosphatase (DUT))
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This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].
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Featured Deoxyuridine Triphosphatase Categories
Deoxyuridine Triphosphatase 抗体
High quality antibodies with extensive validation data.
Deoxyuridine Triphosphatase ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Deoxyuridine Triphosphatase 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Deoxyuridine Triphosphatase 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (1)
- (5)
Cat. No.
ABIN560672
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7260715
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7266736
Quantity
100 μL
Datasheet
Datasheet
Recommended Deoxyuridine Triphosphatase ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966332
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1129512
Quantity
96 tests
Datasheet
Datasheet
Recommended Deoxyuridine Triphosphatase 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122640
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122639
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352151
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Deoxyuridine Triphosphatase Products
: "The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis." in: Molecular cancer therapeutics, Vol. 14, Issue 10, pp. 2332-42, (2015) (PubMed).: "Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme." in: The Journal of biological chemistry, Vol. 282, Issue 46, pp. 33572-82, (2007) (PubMed).
: "Modulation of human dUTPase using small interfering RNA." in: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 306-10, (2005) (PubMed).
: "The role of dUTPase and uracil-DNA repair in cancer chemotherapy." in: Current protein & peptide science, Vol. 2, Issue 4, pp. 361-70, (2002) (PubMed).
Synonyms and alternative names related to Deoxyuridine Triphosphatase
deoxyuridine triphosphatase (DUT), Deoxyuridine triphosphatase (dUTPase), deoxyuridine triphosphatase (P18), dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 (AlHV1gp51), deoxyuridine triphosphatase (UL50), deoxyuridine triphosphatase (HVT058), involved in nucleotide metabolism (UL50), deoxyuridine triphosphatase (ORF9), deoxyuridine triphosphatase (ORF8), tegument protein (U45), dUTPase (GAMMAHV.ORF54), deoxyuridine triphosphatase (Tc00.1047053509151.130), deoxyuridine triphosphatase (Tc00.1047053508175.160), deoxyuridine triphosphatase (Tb927.7.5160), deoxyuridine triphosphatase L homeolog (dut.L), deoxyuridine triphosphatase (Dut), 5031412I06Rik, 5133400F09Rik, anon-SAGE:Wang-077, BcDNA:LD08534, CG4584, D2Bwg0749e, Dmel\\CG4584, Dutp, dUTPase, dutpase, LD08534, PIP4, Tb07.27E10.390, UTPaseProtein level used designations for Deoxyuridine Triphosphatase
- dUTP pyrophosphatase
- CG4584-PA
- CG4584-PB
- CG4584-PC
- CG4584-PD
- anon-SAGE:Wang-077
- dUTPase-PA
- dUTPase-PB
- dUTPase-PC
- dUTPase-PD
- deoxyuridine triphosphatase
- deoxyuridine 5'-triphosphate nucleotidohydrolase
- deoxyuridine triphosphatase, dUTPase, P18
- dUTP nucleotidohydrolase
- deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- PPAR-interacting protein 4
- dUTPase
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