DCLK1 产品
(Doublecortin-Like Kinase 1 (DCLK1))
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This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010].
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Featured DCLK1 Categories
DCLK1 抗体
High quality antibodies with extensive validation data.
DCLK1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
DCLK1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DCLK1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN7436015
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (5)
Cat. No.
ABIN563973
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN6923105
Quantity
200 μL
Datasheet
Datasheet
Recommended DCLK1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6962004
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955456
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966422
Quantity
96 tests
Datasheet
Datasheet
Recommended DCLK1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5570627
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122703
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351192
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our DCLK1 Products
: "DCLK-1 LEVEL IN MULTIPLE SCLEROSIS PATIENTS AND ITS CORRELATION WITH CLINIC." in: Multiple sclerosis and related disorders, Vol. 43, pp. 102179, (2020) (PubMed).: "Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells." in: Oncology reports, Vol. 38, Issue 5, pp. 3238-3244, (2018) (PubMed).
: "Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice." in: EBioMedicine, Vol. 8, pp. 60-71, (2017) (PubMed).
: "DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer." in: Journal of cancer research and clinical oncology, Vol. 142, Issue 10, pp. 2131-40, (2017) (PubMed).
: "Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 124, Issue 11, pp. 958-965, (2017) (PubMed).
: "Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma." in: Cancer prevention research (Philadelphia, Pa.), Vol. 10, Issue 1, pp. 55-66, (2017) (PubMed).
: "Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine." in: Data in brief, Vol. 10, pp. 551-556, (2017) (PubMed).
: "miR-613 inhibits the growth and invasiveness of human hepatocellular carcinoma via targeting DCLK1." in: Biochemical and biophysical research communications, Vol. 473, Issue 4, pp. 987-92, (2016) (PubMed).
: "Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential." in: American journal of physiology. Gastrointestinal and liver physiology, pp. ajpgi.00244.2015, (2015) (PubMed).
: "Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells." in: PLoS ONE, Vol. 10, Issue 2, pp. e0118933, (2015) (PubMed).
Synonyms and alternative names related to DCLK1
doublecortin like kinase 1 (DCLK1), doublecortin-like kinase 1a (dclk1a), serine/threonine-protein kinase DCLK1 (LOC587664), doublecortin-like kinase 2 (dclk2), serine/threonine-protein kinase DCLK1 (LOC100539645), doublecortin-like kinase 1 (Dclk1), doublecortin-like kinase 1 (DCLK1), doublecortin like kinase 1 (Dclk1), 1700113D08Rik, 2810480F11Rik, AI836758, Ania4, CL1, Click-I, CLICK1, Cpg16, DCAMKL1, dcamkl1, Dcamkl1, DCDC3A, Dcl, DCLK, Dclk, DCLK1, dclk1, MGC145348, mKIAA0369, wu:fc51f11, zgc:153709Protein level used designations for DCLK1
- doublecortin-like kinase 1
- doublecortin and CaM kinase-like 1
- doublecortin and calcium/calmodulin-dependent protein kinase-like 1
- serine/threonine-protein kinase DCLK1
- doublecortin-like kinase 2
- serine/threonine-protein kinase DCLK1-like
- doublecortin domain-containing protein 3A
- doublecortin-like and CAM kinase-like 1
- CLICK-I beta
- double cortin and calcium/calmodulin-dependent protein kinase-like 1
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