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DCLK2 产品

(Doublecortin-Like Kinase 2 (DCLK2))

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This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010].

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Featured DCLK2 Categories

DCLK2 抗体

High quality antibodies with extensive validation data.

DCLK2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DCLK2 抗体

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Reactivity Human, Mouse
Application WB, ELISA, IF, ICC
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Cat. No. ABIN6258107
Quantity 100 μL
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Reactivity Human
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Cat. No. ABIN1881253
Quantity 400 μL
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Reactivity Human
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  • (2)
Cat. No. ABIN2856229
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Recommended DCLK2 ELISA试剂盒

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Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
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Cat. No. ABIN5648188
Quantity 96 tests
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Recommended DCLK2 蛋白

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Source Insect Cells
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Quantity 10 μg
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Source Escherichia coli (E. coli)
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Cat. No. ABIN7421590
Quantity 100 μg
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Reactivity Human
Source Escherichia coli (E. coli)
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Cat. No. ABIN7423801
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Latest Publications for our DCLK2 Products

Dijkmans, van Hooijdonk, Fitzsimons, Vreugdenhil: "The doublecortin gene family and disorders of neuronal structure." in: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, (2010) (PubMed).

Kerjan, Koizumi, Han, Dubé, Djakovic, Patrick, Baram, Heinemann, Gleeson: "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 16, pp. 6766-71, (2009) (PubMed).

Gorelik, Sapir, Reiner: "Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene." in: Cellular & molecular biology letters, Vol. 13, Issue 4, pp. 614-20, (2008) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Synonyms and alternative names related to DCLK2

doublecortin like kinase 2 (DCLK2), doublecortin-like kinase 2 (Dclk2), doublecortin-like kinase 2a (dclk2a), 6330415M09Rik, AU044875, cb572, CL2, CLICK-II, Click-II, CLICK2, CLIK2, DCAMKL2, Dcamkl2, DCDC3, DCDC3B, DCK2, Dck2, dclk, DCLK2, RGD1308384, sb:cb572, si:dkey-180n16.1

Protein level used designations for DCLK2

  • CaMK-like CREB regulatory kinase 2
  • doublecortin and CaM kinase-like 2
  • doublecortin domain-containing protein 3B
  • doublecortin-like and CAM kinase-like 2
  • serine/threonine-protein kinase DCLK2
  • caMK-like CREB regulatory kinase 2
  • doublecortin-like kinase 2
  • zDCLK
  • doublecortin kinase 2
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