Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Bisogno, Howell, Williams, Minassi, Cascio, Ligresti, Matias, Schiano-Moriello, Paul, Williams, Gangadharan, Hobbs, Di Marzo, Doherty: "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain." in: The Journal of cell biology, Vol. 163, Issue 3, pp. 463-8, (2003) (PubMed).