CYP27B1 产品
(Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008].
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Featured CYP27B1 Categories
CYP27B1 抗体
High quality antibodies with extensive validation data.
CYP27B1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CYP27B1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP27B1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
- (4)
Cat. No.
ABIN7442201
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IHC (p), FACS
Validations
- (4)
- (4)
Cat. No.
ABIN652999
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7442240
Quantity
100 μL
Datasheet
Datasheet
Recommended CYP27B1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6975506
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966248
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966247
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP27B1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350954
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7414354
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7407907
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CYP27B1 Products
: "Polymorphisms of CYP27B1 are associated with IFN efficacy in HBeAg-positive patients." in: Journal of clinical laboratory analysis, Vol. 32, Issue 5, pp. e22367, (2018) (PubMed).: "Lead Affects Vitamin D Metabolism in Rats." in: Nutrients, Vol. 10, Issue 3, (2018) (PubMed).
: "Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 10, pp. 1865-1876, (2016) (PubMed).
: "25(OH)D Is Effective to Repress Human Cholangiocarcinoma Cell Growth through the Conversion of 25(OH)D to 1α,25(OH)₂D₃." in: International journal of molecular sciences, Vol. 17, Issue 8, (2016) (PubMed).
: "A novel bile salts-lipase polymeric film-infused minitablet system for enhanced oral delivery of cholecalciferol." in: Pharmaceutical development and technology, pp. 1-15, (2015) (PubMed).
: "Reduced sinonasal levels of 1?-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps." in: International forum of allergy & rhinology, (2015) (PubMed).
: "Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1?-hydroxylase expression in the developing rat." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L1018-26, (2015) (PubMed).
: "Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis." in: The Journal of allergy and clinical immunology, Vol. 134, Issue 2, pp. 342-349.e1, (2014) (PubMed).
: "Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets." in: The Journal of steroid biochemistry and molecular biology, Vol. 89-90, Issue 1-5, pp. 121-5, (2004) (PubMed).
: "Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney." in: Journal of the American Society of Nephrology : JASN, Vol. 10, Issue 12, pp. 2465-73, (2000) (PubMed).
Synonyms and alternative names related to CYP27B1
cytochrome P450 family 27 subfamily B member 1 (cyp27b1), cytochrome P450 family 27 subfamily B member 1 (CYP27B1), cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1), cytochrome P450, family 27, subfamily b, polypeptide 1 (Cyp27b1), cp2b, CP2B, Cp2b, cyp1, CYP1, Cyp1, cyp1alpha, CYP1alpha, cyp27b, CYP27B, Cyp27b, Cyp40, p450c1, P450c1, pddr, PDDR, Pddr, vdd1, VDD1, Vdd1, vddr, VDDR, Vddr, vddri, VDDRI, VddrI, vdr, VDR, VdrProtein level used designations for CYP27B1
- cytochrome P450, family 27, subfamily B, polypeptide 1
- 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
- mitochondrial 25 hydroxyvitamin D3-1alpha-hydroxylase
- 1alpha(OH)ase
- 25 hydroxyvitamin D3-1-alpha hydroxylase
- 25-OHD-1 alpha-hydroxylase
- VD3 1A hydroxylase
- calcidiol 1-monooxygenase
- cytochrome P450 subfamily XXVIIB polypeptide 1
- cytochrome P450C1 alpha
- cytochrome P450VD1-alpha
- cytochrome p450 27B1
- 25-hydroxyvitamin D(3) 1-alpha-hydroxylase
- P450C1 alpha
- P450VD1-alpha
- cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
- cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1
- cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
- cytochrome P450, subfamily 27b, polypeptide 1
- 25(OH)D 1alpha-hydroxylase
- 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha)
- 25-hydroxyvitamin D3 1alpha-hydroxylase
- P450VD1alpha
- cytochrome P450, 27b1
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