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Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) 抗体

(Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene\; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
CDKN2A 抗体  (C-Term) CDKN2A 抗体  (C-Term) CDKN2A 抗体 (C-Term) (ABIN1981278)

CDKN2A 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB19093 unconjugated

CDKN2A 抗体 CDKN2A 抗体 CDKN2A 抗体 (ABIN6139280)

CDKN2A 适用: 人 WB, IF, IHC 宿主: 兔 Monoclonal unconjugated

CDKN2A 抗体  (pSer140) CDKN2A 抗体  (pSer140) CDKN2A 抗体 (pSer140) (ABIN6241061)

CDKN2A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB21280 unconjugated

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Find Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) 抗体 for a variety of species such as anti-Human Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4), anti-Mouse Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4). The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC (p), FACS
Validations
  • (1)
  • (5)
Cat. No. ABIN1981278
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC
Validations
  • (4)
Cat. No. ABIN6139280
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN6241061
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN6243104
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6243105
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application DB
Validations
  • (1)
Cat. No. ABIN6241060
Quantity 400 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN3030639
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN3030638
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, DB
Validations
  • (2)
Cat. No. ABIN3030641
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN1538376
Quantity 400 μL
Datasheet Datasheet

Latest Publications for our Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) 抗体

Baik, Mehta, Chung: "Medroxyprogesterone Acetate Prevention of Cervical Cancer through Progesterone Receptor in a Human Papillomavirus Transgenic Mouse Model." in: The American journal of pathology, Vol. 189, Issue 12, pp. 2459-2468, (2020) (PubMed).

Li, Zeng, Xing, Gullicksrud, Shan, Choi, Badovinac, Crotty, Peng, Xue: "Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf." in: Nature communications, Vol. 9, Issue 1, pp. 5452, (2019) (PubMed).

Michalak, Milevskiy, Joyce, Dekkers, Jamieson, Pal, Dawson, Hu, Orkin, Alexander, Lindeman, Smyth, Visvader: "Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids." in: PLoS biology, Vol. 16, Issue 8, pp. e2004986, (2019) (PubMed).

Novais, Diekman, Shapiro, Risbud: "p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence." in: Matrix biology : journal of the International Society for Matrix Biology, (2019) (PubMed).

Rui, Chen, Li, Xiao, Geng, Wang, Xu, Zhang, Dai: "CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging." in: Stem cells international, Vol. 2019, pp. 6257537, (2019) (PubMed).

Ji, Zheng, Liu, Ren, Gao, Zhang, Li: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." in: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).

Han, Li, Zhang, Qin, Yang, Wang, Yuan, Xia: "Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells." in: International journal of oncology, Vol. 51, Issue 5, pp. 1439-1448, (2018) (PubMed).

Rosell��-Díez, Madisen, Bastide, Zeng, Joyner: "Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice." in: PLoS biology, Vol. 16, Issue 6, pp. e2005086, (2018) (PubMed).

Xiong, Yang, Yang, Zhao, Tang, Ran: "Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer." in: International journal of oncology, Vol. 52, Issue 1, pp. 279-287, (2018) (PubMed).

Zhu, Xiao, Tang, Zou, Li, Zhang, Wang, Tang: "Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor." in: Clinical and experimental pharmacology & physiology, Vol. 45, Issue 8, pp. 832-840, (2018) (PubMed).

Aliases for Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) 抗体

cyclin dependent kinase inhibitor 2A (CDKN2A) 抗体
cyclin-dependent kinase inhibitor 2A (Cdkn2a) 抗体
cyclin-dependent kinase inhibitor 2A (LOC100340625) 抗体
cyclin-dependent kinase inhibitor 2A (LOC100731972) 抗体
ADP ribosylation factor-like 2 (Arl2) 抗体
P14ARF () 抗体
ARF 抗体
Arf 抗体
ARF-INK4a 抗体
Arf84D 抗体
Arf84F 抗体
ARL2 抗体
arl2 抗体
Arl84F 抗体
CDK4I 抗体
CDKN2 抗体
CDKN2A 抗体
CG 7435 抗体
CG7435 抗体
CMM2 抗体
Dm Arf84F 抗体
Dmel\CG7435 抗体
INK4 抗体
INK4A 抗体
INK4a 抗体
INK4a-ARF 抗体
Ink4a/Arf 抗体
MLM 抗体
MTS-1 抗体
MTS1 抗体
P14 抗体
P14ARF 抗体
p14ARF 抗体
P16 抗体
p16 抗体
p16(INK4a) 抗体
P16-INK4A 抗体
p16Cdkn2a 抗体
P16INK4 抗体
P16INK4A 抗体
p16INK4a 抗体
p16INK4A 抗体
P19 抗体
p19 抗体
P19ARF 抗体
p19ARF 抗体
Pctr1 抗体
Q06849 抗体
TP16 抗体
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