This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
Eriksson, Le Joncour, Jahkola, Juteau, Laakkonen, Saksela, Hölttä: "Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls." in: Molecular oncology, Vol. 14, Issue 4, pp. 742-762, (2020) (PubMed).
Eriksson, Le Joncour, Nummela, Jahkola, Virolainen, Laakkonen, Saksela, Hölttä: "Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression." in: Oncotarget, Vol. 7, Issue 12, pp. 15065-92, (2017) (PubMed).
Kim, Baek, Yim, Kim, Jeong, Kang, Oh, Lee, Kim, Kim: "Collagen triple helix repeat containing-1 (CTHRC1) expression in invasive ductal carcinoma of the breast: the impact on prognosis and correlation to clinicopathologic features." in: Pathology oncology research : POR, Vol. 19, Issue 4, pp. 731-7, (2013) (PubMed).
Park, Kim, Jo, Kim, Hwang, Kim, Song, Lee, Koh: "Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells." in: Carcinogenesis, Vol. 34, Issue 3, pp. 694-702, (2013) (PubMed).