(CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 (CTDP1))
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
Chan, Marshall, Saffery, Kim, Earle, Choo, Wong: "Active transcription and essential role of RNA polymerase II at the centromere during mitosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 6, pp. 1979-84, (2012) (PubMed).
Aliases for CTDP1 抗体
CTD phosphatase subunit 1 (Ctdp1) 抗体 CTD phosphatase subunit 1 (CTDP1) 抗体 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (ctdp1) 抗体 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (CTDP1) 抗体 RNA polymerase II subunit A C-terminal domain phosphatase (ANI_1_2668024) 抗体 RNA polymerase II subunit A C-terminal domain phosphatase (AOR_1_1228154) 抗体 RNA polymerase II subunit A C-terminal domain phosphatase (CpipJ_CPIJ004583) 抗体 RNA polymerase II subunit A C-terminal domain phosphatase (PTRG_11566) 抗体 CTD phosphatase Fcp1 (SJAG_01286) 抗体 RNA polymerase II subunit A C-terminal domain phosphatase (MCYG_05528) 抗体 RNA polymerase II subunit A C-terminal domain phosphatase (VDBG_09811) 抗体 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (Ctdp1) 抗体 4930563P03Rik 抗体 AW553592 抗体 CCFDN 抗体 CTDP1 抗体 FCP1 抗体