CSK 蛋白
(C-Src tyrosine Kinase (CSK))
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| CSK Protein (AA 1-450) (GST tag) | 人 | 小麦胚 |
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| CSK Protein (AA 1-450) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| CSK Protein (GST tag) | 人 | Baculovirus infected Insect Cells |
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| CSK Protein (His-GST) | 小鼠 | Baculovirus infected Insect Cells |
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| CSK 蛋白 | 小鼠 | Baculovirus infected Insect Cells |
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| CSK 蛋白 | 人 | Baculovirus infected Insect Cells |
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| CSK Protein (GST tag) | 人 | Baculovirus infected Insect Cells |
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| CSK Protein (AA 1-229) (His-IF2DI Tag) | 人 | 大肠杆菌（E. Coli） |
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| CSK 蛋白 | 人 | 大肠杆菌（E. Coli） |
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| CSK Protein (His-GST) | 小鼠 | Baculovirus infected Insect Cells |
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| CSK Protein (His-GST) | 人 | Baculovirus infected Insect Cells |
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| CSK 蛋白 | 人 | Insect Cells |
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| CSK Protein (AA 243-438) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| CSK Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| CSK Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| CSK Protein (AA 2-450) (His tag) | Cow | 酵母菌 |
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| CSK Protein (AA 2-450) (His tag) | 大鼠 | 酵母菌 |
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| CSK Protein (AA 1-450) (His tag) | 小鸡 | 酵母菌 |
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| CSK Protein (AA 1-450) (His tag) | 人 | Bacteria |
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| CSK Protein (His tag) | 人 | 大肠杆菌（E. Coli） |
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Protein
- AP (Affinity Purification: 所列应用)
- AA (Antibody Array: 所列应用)
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
1 reference - 宿主
- 人
- 宿主
- 小麦胚
- 蛋白类型
- Recombinant
Protein
- SDS (SDS-PAGE: 有验证图片)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 人
- 宿主
- Baculovirus infected Insect Cells
- 蛋白类型
- Recombinant
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 小鼠
- 宿主
- Baculovirus infected Insect Cells
- 蛋白类型
- Recombinant
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- 宿主
- 人
- 宿主
- Baculovirus infected Insect Cells
- 蛋白类型
- Recombinant
- 生物活性
- Active
Protein
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- 宿主
- 小鼠
- 宿主
- Baculovirus infected Insect Cells
- 蛋白类型
- Recombinant
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- 宿主
- 人
- 宿主
- Baculovirus infected Insect Cells
- 蛋白类型
- Recombinant
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- WB (Western Blotting: 有验证图片)
- AcA (Activity Assay: 有验证图片)
- Func (Functional Studies: 所列应用)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- PI (Protein Interaction: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- 生物活性
- Active
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- Cow
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- 大鼠
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- 小鸡
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- Imm (Immunogen: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
Latest Publications for our CSK 蛋白
: "SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91582, (2014) (PubMed).
Aliases for CSK 蛋白
C-terminal Src kinase (CSK) 蛋白c-src tyrosine kinase (Csk) 蛋白
C-terminal Src kinase (Csk) 蛋白
c-src tyrosine kinase (CSK) 蛋白
CSK, non-receptor tyrosine kinase (CSK) 蛋白
AW212630 蛋白
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