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CRBN 产品

(Cereblon (CRBN))

Categories

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Featured CRBN Categories

CRBN 抗体

High quality antibodies with extensive validation data.

CRBN ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CRBN 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CRBN 抗体

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Reactivity Human
Application WB, IHC, ELISA
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Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
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Cat. No. ABIN526543
Quantity 50 μg
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Application WB
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Cat. No. ABIN6744097
Quantity 100 μL
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Recommended CRBN ELISA试剂盒

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Reactivity
Analytical Method
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Cat. No.
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Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6965629
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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  • (1)
Cat. No. ABIN6954563
Quantity 96 tests
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Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
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Cat. No. ABIN6954564
Quantity 96 tests
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Recommended CRBN 蛋白

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Reactivity
Source
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Source Wheat germ
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Cat. No. ABIN1350279
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
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Cat. No. ABIN7122244
Quantity 50 μg
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Reactivity Human
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Latest Publications for our CRBN Products

Donovan, An, Nowak, Yuan, Fink, Berry, Ebert, Fischer: "Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome." in: eLife, Vol. 7, (2019) (PubMed).

Girardini, Maniaci, Hughes, Testa, Ciulli: "Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs." in: Bioorganic & medicinal chemistry, Vol. 27, Issue 12, pp. 2466-2479, (2019) (PubMed).

de Wispelaere, Du, Donovan, Zhang, Eleuteri, Yuan, Kalabathula, Nowak, Fischer, Gray, Yang: "Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations." in: Nature communications, Vol. 10, Issue 1, pp. 3468, (2019) (PubMed).

Zoppi, Hughes, Maniaci, Testa, Gmaschitz, Wieshofer, Koegl, Riching, Daniels, Spallarossa, Ciulli et al.: "Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of ..." in: Journal of medicinal chemistry, (2018) (PubMed).

Olson, Jiang, Erb, Liang, Doctor, Zhang, Zhang, Kwiatkowski, Boukhali, Green, Haas, Nomanbhoy, Fischer, Young, Bradner, Winter, Gray: "Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation." in: Nature chemical biology, Vol. 14, Issue 2, pp. 163-170, (2018) (PubMed).

Basiorka, McGraw, De Ceuninck, Griner, Zhang, Clark, Caceres, Sokol, Komrokji, Reuther, Wei, Tavernier, List: "Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41." in: Cancer research, Vol. 76, Issue 12, pp. 3531-40, (2016) (PubMed).

Peng, Li, Clarkson, Pehar, Lao, Hillmer, Barnhart, Christian, Mitchell, Bendlin, Sandor, Puglielli: "Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 20, pp. 6772-89, (2014) (PubMed).

Liu, Ye, Zou, Xu, Feng, Zou, Chen, Li, Cang: "CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis." in: Nature communications, Vol. 5, pp. 3924, (2014) (PubMed).

Gandhi, Mendy, Waldman, Chen, Rychak, Miller, Gaidarova, Ren, Wang, Breider, Carmel, Mahmoudi, Jackson, Abbasian, Cathers, Schafer, Daniel, Lopez-Girona, Thakurta, Chopra: "Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity." in: British journal of haematology, Vol. 164, Issue 2, pp. 233-44, (2014) (PubMed).

Charoenfuprasert, Yang, Lee, Chao, Chu, Lai, Hsu, Chang, Chen, Chen, Chang, Leu, Shih: "Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer." in: Oncogene, Vol. 30, Issue 33, pp. 3570-84, (2011) (PubMed).

Synonyms and alternative names related to CRBN

cereblon (crbn), cereblon (CRBN), ATP-dependent protease La (LON) domain protein (AT2G25740), cereblon (Crbn), 2610203G15Rik, 2900045O07Rik, AF229032, AW108261, F3N11.21, MRT2, mrt2a, MRT2A, piL, zgc:92404

Protein level used designations for CRBN

  • protein cereblon
  • zcrbn
  • cereblon
  • protein cereblon-like
  • protein x 0001
  • novel lethal
  • protein PiL
  • Protein cereblon
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