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- Key Features
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- Rabbit anti-CRBN Antibody reliably detects CRBN in human species.
- Polyclonal, unconjugated antibody for ELISA, WB, IHC.
- Highly specific CRBN detection. See validation images.
- 抗原 See all CRBN 抗体
- CRBN (Cereblon (CRBN))
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抗原表位
- AA 1-280
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CRBN antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人, 小鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Protein cereblon protein (1-280AA)
- 亚型
- IgG
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anti-Cereblon (CRBN) (AA 1-442) antibody
CRBN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cereblon (CRBN) (AA 35-84) antibodyCRBN 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- CRBN (Cereblon (CRBN))
- 别名
- CRBN (CRBN 产品)
- 别名
- zgc:92404 antibody, mrt2a antibody, F3N11.21 antibody, MRT2 antibody, MRT2A antibody, 2610203G15Rik antibody, 2900045O07Rik antibody, AF229032 antibody, AW108261 antibody, piL antibody, cereblon antibody, ATP-dependent protease La (LON) domain protein antibody, crbn antibody, CRBN antibody, AT2G25740 antibody, Crbn antibody
- 背景
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Background: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
Aliases: 2610203G15Rik antibody, 2900045O07Rik antibody, AF229032 antibody, AW108261 antibody, Cereblon antibody, Crbn antibody, CRBN_HUMAN antibody, DKFZp781K0715 antibody, MGC27358 antibody, MRT2A antibody, OTTHUMP00000209555 antibody, piL antibody, Protein cereblon antibody, Protein x 0001 antibody
- UniProt
- Q96SW2
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